Osteoconductivity of modified fluorcanasite glass-ceramics for bone tissue augmentation and repair
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2010-09-01
Autores
Bandyopadhyay-Ghosh, S.
Faria, P. E. P.
Johnson, A.
Felipucci, D. N. B.
Reaney, I. M.
Salata, L. A.
Brook, I. M.
Hatton, P. V.
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Modified fluorcanasite glasses were fabricated by either altering the molar ratios of Na 2O and CaO or by adding P 2O 5 to the parent stoichiometric glass compositions. Glasses were converted to glass-ceramics by a controlled two-stage heat treatment process. Rods (2 mm x 4 mm) were produced using the conventional lost-wax casting technique. Osteoconductive 45S5 bioglass was used as a reference material. Biocompatibility and osteoconductivity were investigated by implantation into healing defects (2 mm) in the midshaft of rabbit femora. Tissue response was investigated using conventional histology and scanning electron microscopy. Histological and histomorphometric evaluation of specimens after 12 weeks implantation showed significantly more bone contact with the surface of 45S5 bioglass implants when compared with other test materials. When the bone contact for each material was compared between experimental time points, the Glass-Ceramic 2 (CaO rich) group showed significant difference (p = 0.027) at 4 weeks, but no direct contact at 12 weeks. Histology and backscattered electron photomicrographs showed that modified fluorcanasite glass-ceramic implants had greater osteoconductivity than the parent stoichiometric composition. Of the new materials, fluorcanasite glass-ceramic implants modified by the addition of P 2O 5 showed the greatest stimulation of new mineralized bone tissue formation adjacent to the implants after 4 and 12 weeks implantation. © 2010 Wiley Periodicals, Inc.
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45S5 bioglass, Bone tissue, Fluorcanasite, Glass-ceramic, In vivo biocompatibility, Osteoconductivity, Backscattered electrons, Bio-glass, Bone contacts, Direct contact, Glass compositions, Heat treatment process, In-vivo, Mineralized bone, Molar ratio, New material, Osteoconductive, Reference material, Stoichiometric compositions, Test materials, Time points, Tissue response, Two stage, Wax casting, Biocompatibility, Glass ceramics, Histology, Scanning electron microscopy, Secondary batteries, Sodium, Bone, fluorcanasite glass, glass, unclassified drug, animal experiment, animal model, animal tissue, biocompatibility, bone defect, bone remodeling, bone tissue augmentation, bone tissue repair, ceramics, female, femur shaft, histopathology, morphometrics, nonhuman, rabbit, scanning electron microscopy, Animals, Biocompatible Materials, Bone and Bones, Bone Substitutes, Ceramics, Female, Implants, Experimental, Materials Testing, Rabbits, Random Allocation, Silicates
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Journal of Biomedical Materials Research - Part A, v. 94, n. 3, p. 760-768, 2010.