3,5-Dimethyl-1-thiocarbamoylpyrazole and its Pd(II) complexes: Synthesis, spectral studies and antitumor activity
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Data
2010-05-01
Autores
Rocha, F. V. [UNESP]
Barra, C. V. [UNESP]
Netto, Adelino Vieira de Godoy [UNESP]
Mauro, Antonio Eduardo [UNESP]
Carlos, I. Z. [UNESP]
Frem, Regina Célia Galvão [UNESP]
Ananias, S. R. [UNESP]
Quilles, M. B. [UNESP]
Stevanato, A. [UNESP]
da Rocha, M. C. [UNESP]
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Elsevier France-editions Scientifiques Medicales Elsevier
Resumo
Complexes of the type [PdX(2)(tdmPz)] {X = Cl(-)(1) Br(-)(2); l(-)(3); SCN(-)(4); tdmPz = 1-thiocarbamoy1-3,5-dimethylpyrazole} have been synthesized and characterized. Compound 1 was formed from the reaction between [PdCl(2)(CH(3)CN)(2)] and 1-thiocarbamoy1-3,5-dimethylpyrazole. Complexes 2, 3 and 4 were obtained by metathesis of the chloro groups from 1 by bromide, iodide and thiocyanate ions, respectively. All the compounds and cisplatin have been tested in vitro by WIT assay for their cytotoxicity against three murine cancer cell lines: mammary adenocarcinoma (LM3 and LMM3) and lung adenocarcinoma (LP07) as well towards normal murine peritoneal exudate cells (PEC). Promising cytotoxic effect against LM3 has been found for 3 showing IC(50) equal to 24.5 mu M which is comparable to the value obtained for cisplatin (30.3 mu M). (C) 2010 Elsevier Masson SAS. All rights reserved.
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Palavras-chave
Pd(II) complexes, 1-Thiocarbamoyl-3,5-dimethylpyrazole, Spectroscopy, Antitumor activity
Como citar
European Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 45, n. 5, p. 1698-1702, 2010.