Anxiolytic-like effects of erythrinian alkaloids from erythrina suberosa
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Data
2011-01-01
Autores
Serrano, Maria Amélia Rodrigues [UNESP]
Batista, Andrea Nastri de Luca [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
Santos, Luciana de Ávila [UNESP]
Nogueira, Paulo José de Campos [UNESP]
Nunes-de-Souza, Ricardo Luiz [UNESP]
Latif, Abdul
Arfan, Mohammad
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Química
Resumo
Two alkaloids, erysodine (1) and erysothrine (2) were isolated from the flowers of a Pakistani medicinal plant, Erythrina suberosa. These compounds were investigated for anxiolytic properties, and the results showed significant effect, in an acute oral treatment with 1-2, which were suspended in saline (NaCl 0.9%) plus DMSO 1%, and evaluated in 122 Swiss male mice exposed to two tests of anxiety - the elevated plus-maze (EPM) and the light/dark transition model (LDTM).
Descrição
Palavras-chave
anxyolitic activity, E. suberosa, erythrinian alkaloids
Como citar
Química Nova. Sociedade Brasileira de Química, v. 34, n. 5, p. 808-811, 2011.