Efeitos a longo prazo de alterações de dieta numa fase precoce da vida sobre o crescimento posterior: estudo experimental em ratos jovens
Carregando...
Data
2001
Autores
Battochio, Ana Paula Ronquesel [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Estadual Paulista (Unesp)
Resumo
CARAMORI, 1996 realizou um trabalho, em nosso Laboratório Experimental de Pediatria, avaliando diferentes momentos de desmame e diferentes momentos de ligadura do colédoco. Como resultado desta pesquisa o autor pode concluir que parece ser crítico para o crescimento do animal (ratos), o nível de lipídios aproveitados no período dos 21 aos 28 dias de vida. A partir desta hipótese nos propomos a estudar o assunto, fazer esta revisão na literatura e a realização do trabalho experimental. O objetivo desse trabalho é testar diferentes dietas no período de 21 aos 28 dias de vida em ratos e avaliar as repercussões sobre o crescimento posterior. Estudaram-se 40 ratos machos, divididos em grupos de 10 animais, dos 21 aos 28 dias e submetidos a uma das seguintes dietas: G1-aleitamento materno; G2: ração padrão do laboratório ad libitum; G3: ração padrão em quantidade igual à metade da ingerida pelo G2; G4: ração sem lipídeos. Dos 28 aos 70 dias todos os animais receberam ração padrão. As análises de variância com um fator, ou análise de Kruskal-Wallis, comparação múltipla e o teste de S.N.K p ≤ 0,05: mostraram que o grupo com restrição calórica (G3) foi o grupo que obteve maior crescimento ao final do processo, H=16,373, p≤0,001 e CVAC menor do que o G2, F=9,653; p≤ 0,00. A restrição lipídica no período dos 21 aos 28 dias de idade associouse a menor peso fresco do coração. Não demonstramos diferença entre as dietas sobre o conteúdo de água e gordura do coração. O aleitamento materno no período dos 21 aos 28 dias de idade apresentou peso fresco do fígado menor do que a ração padronizada. A restrição lipídica no período dos 21 aos 28 dias de idade apresentou maior conteúdo de água do que a ração padronizada. Não demonstramos diferença entre as dietas sobre o conteúdo de gordura do fígado.
Caramori, 1996 relized one label, in our Pediatry Experiment Laboratory, avaliating differents moments of weaning and differentes moments of double ligature and resection of common bile duct. How result of this work, the author cans to conclude that appear to be critic to the animal’s growing (rats), the level of lipidic profit in the period by the 21 at 28 days of life. By the way of these hypothesis we propose to study the object, to make this revision in the literature and the realization of experiment work. The objective of this work is to test differents diets in the period by the 21 at 28 days of live in rats and to avalue the repercutions about the growing posterior. Studies 40 male rats, divided in group of 10 animals, by the 21 at 28 days submitted to one of the following diets: G1: breast feeding; G2: standard ration of Laboratory “ad libitum”; G3: standard ration in quantity same at middle of ingested to the G2; G4: ration without lipidic. By the 29 aos 70 days all the animals received standard ration. The analyses of variancy with one factor, or analyses of Kruskal-Wallis, comparation multipe and the test of S.N.K p ≤ 0,05: shoned that the group with restriction caloric(G3) was the group that obtained bigger growing at the final of process, H=16,373, p≤ 0,001 e CVAC less than the G2, F=9,653; p≤0,001. The restriction lipidic in period of the 21 at 28 days of age associated the less fresh weight of heart. Don’t showed difference between the diets about the contents of water and heart’s fat. The breast feeding in the period by the 21 at 28 days of age presented fresh weight of liver less than the standard ration. The lipidic restriction in the period of 21 at 28 days of age presented bigger contents of water than the standard ration. Don’t showed difference between the diets about the contents of liver’s fat.
Caramori, 1996 relized one label, in our Pediatry Experiment Laboratory, avaliating differents moments of weaning and differentes moments of double ligature and resection of common bile duct. How result of this work, the author cans to conclude that appear to be critic to the animal’s growing (rats), the level of lipidic profit in the period by the 21 at 28 days of life. By the way of these hypothesis we propose to study the object, to make this revision in the literature and the realization of experiment work. The objective of this work is to test differents diets in the period by the 21 at 28 days of live in rats and to avalue the repercutions about the growing posterior. Studies 40 male rats, divided in group of 10 animals, by the 21 at 28 days submitted to one of the following diets: G1: breast feeding; G2: standard ration of Laboratory “ad libitum”; G3: standard ration in quantity same at middle of ingested to the G2; G4: ration without lipidic. By the 29 aos 70 days all the animals received standard ration. The analyses of variancy with one factor, or analyses of Kruskal-Wallis, comparation multipe and the test of S.N.K p ≤ 0,05: shoned that the group with restriction caloric(G3) was the group that obtained bigger growing at the final of process, H=16,373, p≤ 0,001 e CVAC less than the G2, F=9,653; p≤0,001. The restriction lipidic in period of the 21 at 28 days of age associated the less fresh weight of heart. Don’t showed difference between the diets about the contents of water and heart’s fat. The breast feeding in the period by the 21 at 28 days of age presented fresh weight of liver less than the standard ration. The lipidic restriction in the period of 21 at 28 days of age presented bigger contents of water than the standard ration. Don’t showed difference between the diets about the contents of liver’s fat.
Descrição
Palavras-chave
Crianças - Crescimento, Children - Growth
Como citar
BATTOCHIO, Ana Paula Ronquesel. Efeitos a longo prazo de alterações de dieta numa fase precoce da vida sobre o crescimento posterior: estudo experimental em ratos jovens. 2001. 183 f. Dissertação (mestrado) - Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, 2001.