Factors that may influence polymorphous low-grade adenocarcinoma growth

Soares, Andresa Borges; Martinez, Elizabeth Ferreira; Avila Ribeiro, Patricia Fernandes; Barreto, Icleia Siqueira; Aguiar, Maria Cassia; Furuse, Cristiane [UNESP]; Sperandio, Marcelo; Montalli, Victor Angelo; Araujo, Ney Soares de; Araujo, Vera Cavalcanti de

Factors that may influence polymorphous low-grade adenocarcinoma growth

Arquivos

WOS000399037800010.pdf (1.16 MB)

Data

2017-04-01

Autores

Soares, Andresa Borges

Martinez, Elizabeth Ferreira

Avila Ribeiro, Patricia Fernandes

Barreto, Icleia Siqueira

Aguiar, Maria Cassia

Furuse, Cristiane

Sperandio, Marcelo

Montalli, Victor Angelo

Araujo, Ney Soares de

Araujo, Vera Cavalcanti de

Editor

Springer

Tipo

Artigo

Direito de acesso

Acesso aberto

Resumo

There is mounting evidence on the importance of some biological processes in tumor growth, such as vascular supply, apoptosis, autophagy, and senescence. We have investigated these processes in polymorphous low-grade adenocarcinoma (PLGA), in an attempt to identify those that are relevant for this particular lesion. We analyzed 31 cases of PLGA using immunohistochemistry to antibodies against CD34 and CD105 to detect blood vessels; against D2-40 to detect lymphatic vessels; against Bax, Bcl-2, and survivin to explore cell apoptosis; and against Beclin and LCB3 to investigate autophagy and against p21 and p16 to assess senescence. Our results showed that PLGA growth does not depend on newly formed vessels but only on preexisting vasculature. Furthermore, PLGA is promoted by autophagy, sustained by both anti-apoptotic and anti-senescence signals, and stimulated by Bcl-2 and survivin.