Flavonoides e a influência na perda de massa e na composição corporal: uma alternativa no tratamento da obesidade
Carregando...
Data
2023-08-17
Autores
Garcia, Izabella Cristinny Lacerda
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Estadual Paulista (Unesp)
Resumo
Introdução: Nas últimas décadas, o mundo observou o aumento da prevalência da obesidade, atingindo níveis pandêmicos, resultando em um grande aumento na incidência de diversas comorbidades, como as doenças cardiovasculares, diabetes tipo 2 e câncer, acarretando enormes prejuízos à saúde das pessoas, e grandes encargos socioeconômicos. A conduta farmacológica para tratamento antiobesidade ganhou força, no entanto, apresenta limitações devido a eventos adversos significativos, baixa eficácia, alto custo, e dependência da adesão do paciente a uma alimentação saudável e exercícios (RUFINO et al., 2020). O consumo de compostos bioativos, presentes em frutas e verduras, ou ainda como suplementos nutracêuticos, entre eles os flavonoides, têm mostrado ter papel importante no controle da inflamação e de alterações no metabolismo decorrentes do excesso de peso e gordura corporal (MULVIHILL et al., 2016). Objetivo: O presente trabalho visa explorar a literatura acerca da atividade dos flavonoides e seus possíveis mecanismos de ação sobre a massa e composição corporal. Método: Este trabalho consiste em uma revisão da literatura sobre a influência de flavonoides na massa e na composição corporal como um agente antiobesidade. Para isto, utilizaram-se as principais bases de dados na área de saúde. Discussão: Na literatura é possível encontrar diversos trabalhos apresentando atuação benéfica dos flavonoides na saúde, como no controle da obesidade, melhora na inflamação do tecido adiposo, efeitos protetores contra o estresse oxidativo, diabetes, dislipidemia e doenças cardiovasculares (ALAM et al., 2013, DINDA et al., 2019). Estudos sugerem que os flavonoides demonstram um efeito sobre a obesidade, por sua capacidade de reduzir a massa corporal, a massa gorda e os triglicerídeos/colesterol plasmáticos. Conclusão: O impacto dos flavonoides na obesidade pode ser observado através da modulação da ingestão alimentar, atividades enzimáticas, absorção nutricional, adipogênese e ciclo de vida dos adipócitos, termogênese, consumo de energia e microbiota (RUFINO et al., 2020; SONG et al., 2019). Uma melhor compreensão dos mecanismos antiobesidade dos flavonoides permitirá seu uso potencial para tratar esta condição de saúde.
Introduction: In recent decades, the world has seen an increase in the prevalence of obesity, reaching pandemic levels, resulting in a large increase in the incidence of several comorbidities, such as cardiovascular diseases, type 2 diabetes and cancer, causing enormous damage to people's health, and large socioeconomic burdens. The pharmacological approach for anti-obesity treatment has gained strength, however, it has limitations due to significant adverse events, low efficacy, high cost, and dependence on patient adherence to healthy eating and exercise (RUFINO et al., 2020). The consumption of bioactive compounds, present in fruits and vegetables, or even as nutraceutical supplements, including flavonoids, have been shown to play an important role in controlling inflammation and changes in metabolism resulting from excess weight and body fat (MULVIHILL et al., 2016). Aim: The present work aims to explore the literature about the activity of flavonoids and their possible mechanisms of action on mass and body composition. Method: This work consists of a literature review on the influence of flavonoids on body mass and composition as an anti-obesity agent. For this, the main databases in the health area were used. Discussion: In the literature it is possible to find several works showing the beneficial role of flavonoids in health, such as in the control of obesity, improvement in inflammation of adipose tissue, protective effects against oxidative stress, diabetes, dyslipidemia and cardiovascular diseases (ALAM et al., 2013, DINDA et al., 2019). Studies suggest that flavonoids demonstrate an effect on obesity, due to their ability to reduce body mass, fat mass and plasma triglycerides/cholesterol. Conclusion: The impact of flavonoids on obesity can be observed through the modulation of food intake, enzymatic activities, nutritional absorption, adipogenesis and adipocyte life cycle, thermogenesis, energy consumption and microbiota (RUFINO et al., 2020; SONG et al., 2019). A better understanding of the anti-obesity mechanisms of flavonoids will allow for their potential use to treat this health condition.
Introduction: In recent decades, the world has seen an increase in the prevalence of obesity, reaching pandemic levels, resulting in a large increase in the incidence of several comorbidities, such as cardiovascular diseases, type 2 diabetes and cancer, causing enormous damage to people's health, and large socioeconomic burdens. The pharmacological approach for anti-obesity treatment has gained strength, however, it has limitations due to significant adverse events, low efficacy, high cost, and dependence on patient adherence to healthy eating and exercise (RUFINO et al., 2020). The consumption of bioactive compounds, present in fruits and vegetables, or even as nutraceutical supplements, including flavonoids, have been shown to play an important role in controlling inflammation and changes in metabolism resulting from excess weight and body fat (MULVIHILL et al., 2016). Aim: The present work aims to explore the literature about the activity of flavonoids and their possible mechanisms of action on mass and body composition. Method: This work consists of a literature review on the influence of flavonoids on body mass and composition as an anti-obesity agent. For this, the main databases in the health area were used. Discussion: In the literature it is possible to find several works showing the beneficial role of flavonoids in health, such as in the control of obesity, improvement in inflammation of adipose tissue, protective effects against oxidative stress, diabetes, dyslipidemia and cardiovascular diseases (ALAM et al., 2013, DINDA et al., 2019). Studies suggest that flavonoids demonstrate an effect on obesity, due to their ability to reduce body mass, fat mass and plasma triglycerides/cholesterol. Conclusion: The impact of flavonoids on obesity can be observed through the modulation of food intake, enzymatic activities, nutritional absorption, adipogenesis and adipocyte life cycle, thermogenesis, energy consumption and microbiota (RUFINO et al., 2020; SONG et al., 2019). A better understanding of the anti-obesity mechanisms of flavonoids will allow for their potential use to treat this health condition.
Descrição
Palavras-chave
Obesidade, Flavonoides, massa corporal, Composição corporal