Publicação: Serum thiamine concentration and oxidative stress as predictors of mortality in patients with septic shock
dc.contributor.author | Costa, Nara Aline [UNESP] | |
dc.contributor.author | Gut, Ana Lúcia [UNESP] | |
dc.contributor.author | Dorna, Mariana de Souza [UNESP] | |
dc.contributor.author | Coelho Pimentel, Jose Alexandre | |
dc.contributor.author | Franciscato Cozzolino, Silvia Maria | |
dc.contributor.author | Gaiolla, Paula Schmidt Azevedo [UNESP] | |
dc.contributor.author | Fernandes, Ana Angelica Henrique [UNESP] | |
dc.contributor.author | Zornoff, Leonardo Antonio Mamede [UNESP] | |
dc.contributor.author | Paiva, Sergio Alberto Rupp de [UNESP] | |
dc.contributor.author | Minicucci, Marcos Ferreira [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.date.accessioned | 2014-12-03T13:10:31Z | |
dc.date.available | 2014-12-03T13:10:31Z | |
dc.date.issued | 2014-02-01 | |
dc.description.abstract | Purpose: The purpose of the study is to determine the influence of serum thiamine, glutathione peroxidase (GPx) activity, and serum protein carbonyl concentrations in hospital mortality in patients with septic shock.Materials and Methods: This prospective study included all patients with septic shock on admission or during intensive care unit (ICU) stay, older than 18 years, admitted to 1 of the 3 ICUs of the Botucatu Medical School, from January to August 2012. Demographic information, clinical evaluation, and blood sample were taken within the first 72 hours of the patient's admission or within 72 hours after septic shock diagnosis for serum thiamine, GPx activity, and protein carbonyl determination.Results: One hundred eight consecutive patients were evaluated. The mean age was 57.5 +/- 16.0 years, 63% were male, 54.6% died in the ICU, and 71.3% had thiamine deficiency. Thiamine was not associated with oxidative stress. Neither vitamin B1 levels nor the GPx activity was associated with outcomes in these patients. However, protein carbonyl concentration was associated with increased mortality.Conclusions: In patients with septic shock, oxidative stress was associated with mortality. On the other hand, thiamine was not associated with oxidative stress or mortality in these patients. (C) 2014 Elsevier Inc. All rights reserved. | en |
dc.description.affiliation | Univ Estadual Paulista, Dept Internal Med, Botucatu Med Sch, Botucatu, SP, Brazil | |
dc.description.affiliation | Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, Sao Paulo, Brazil | |
dc.description.affiliation | Univ Estadual Paulista, Dept Chem & Biochem, Inst Biol Sci, Botucatu, SP, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Dept Internal Med, Botucatu Med Sch, Botucatu, SP, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Dept Chem & Biochem, Inst Biol Sci, Botucatu, SP, Brazil | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.format.extent | 249-252 | |
dc.identifier | http://dx.doi.org/10.1016/j.jcrc.2013.12.004 | |
dc.identifier.citation | Journal Of Critical Care. Philadelphia: W B Saunders Co-elsevier Inc, v. 29, n. 2, p. 249-252, 2014. | |
dc.identifier.doi | 10.1016/j.jcrc.2013.12.004 | |
dc.identifier.issn | 0883-9441 | |
dc.identifier.lattes | 5452093689066508 | |
dc.identifier.lattes | 5016839015394547 | |
dc.identifier.lattes | 1213140801402647 | |
dc.identifier.lattes | 7438704034471673 | |
dc.identifier.orcid | 0000-0002-5843-6232 | |
dc.identifier.uri | http://hdl.handle.net/11449/112202 | |
dc.identifier.wos | WOS:000332409400013 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Journal Of Critical Care | |
dc.relation.ispartofjcr | 2.872 | |
dc.relation.ispartofsjr | 1,184 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | Septic shock | en |
dc.subject | Glutathione peroxidase | en |
dc.subject | Mortality | en |
dc.subject | Thiamine | en |
dc.subject | Protein carbonyl | en |
dc.title | Serum thiamine concentration and oxidative stress as predictors of mortality in patients with septic shock | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
dspace.entity.type | Publication | |
unesp.author.lattes | 5016839015394547[7] | |
unesp.author.lattes | 5452093689066508[2] | |
unesp.author.lattes | 1213140801402647[6] | |
unesp.author.lattes | 7438704034471673 | |
unesp.author.orcid | 0000-0002-5980-4367[10] | |
unesp.author.orcid | 0000-0003-4412-1990[9] | |
unesp.author.orcid | 0000-0002-5843-6232[6] | |
unesp.author.orcid | 0000-0001-5763-0829[2] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatu | pt |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatu | pt |
unesp.department | Clínica Médica - FMB | pt |
unesp.department | Química e Bioquímica - IBB | pt |