Gastroprotective effect of Cissus sicyoides (Vitaceae): Involvement of microcirculation, endogenous sulfhydryls and nitric oxide

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dc.contributor.authorFerreira, Marystela [UNESP]
dc.contributor.authorNishijima, Catarine Massucato [UNESP]
dc.contributor.authorSeito, Leonardo Norobu [UNESP]
dc.contributor.authorDokkedal, Anne Lígia [UNESP]
dc.contributor.authorFerreira, Marystela [UNESP]
dc.contributor.authorDi Stasi, Luiz Claudio [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorHiruma-Lima, Clélia Akiko [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto Butantan
dc.date.accessioned2014-05-20T13:49:12Z
dc.date.available2014-05-20T13:49:12Z
dc.date.issued2008-04-17
dc.description.abstractAim of the study: Cissus sicyoides L. is a medicinal plant popularly known in Brazil against various diseases and the research interest in this plant is justifiable because of its potential medicinal value in stomachache and gastric ulcer.Materials and methods: The methanolic extract obtained from the leaves of Cissus sicyoides (Cc) was evaluated for the ability to protect the gastric mucosa against injuries caused by necrotizing agents (0.3 M HCl/60% EtOH, absolute ethanol, piroxicam and pylorus ligature) in rodents. We also evaluated microcirculation, antioxidant action and participation of NO (nitric oxide) and sulfhydryls (SH) groups in the Cc gastroprotective action.Results: Administration of Cc significantly reduced gastric lesions induced by different ulcerogenic agents in rodents. This extract administered by oral route significantly increased gastric volume without exerting antisecretory effect. The Cc effect involved an increase of the defense mechanism of the gastrointestinal mucosa such as NO and SH groups that prevent and attenuate the ulcer process. The Cc also has antioxidant property against oxidative stress but does not modify microcirculation response in gastric mucosa.Conclusions: These results confirmed the traditional use of Cissus sicyoides for the treatment of gastric ulcer. (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, UNESP, CP 510,Biosci Inst, Dept Physiol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, CP 510,Biosci Inst,Lab Phytomed, Dept Pharmacol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, CP 473, Dept Biol, BR-17033360 Bauru, SP, Brazil
dc.description.affiliationInst Butantan, Special Lab Appl Toxinol CAT CEPID, BR-05503900 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, CP 355,Organ Chem Dept, Inst Chem, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, CP 510,Biosci Inst, Dept Physiol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, CP 510,Biosci Inst,Lab Phytomed, Dept Pharmacol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, CP 473, Dept Biol, BR-17033360 Bauru, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, CP 355,Organ Chem Dept, Inst Chem, BR-18618000 Botucatu, SP, Brazil
dc.format.extent170-174
dc.identifierhttp://dx.doi.org/10.1016/j.jep.2008.01.008
dc.identifier.citationJournal of Ethnopharmacology. Clare: Elsevier B.V., v. 117, n. 1, p. 170-174, 2008.
dc.identifier.doi10.1016/j.jep.2008.01.008
dc.identifier.issn0378-8741
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/17515
dc.identifier.wosWOS:000255374400019
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofjcr3.115
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCissus sicyoidesen
dc.subjectvitaceaeen
dc.subjectgastroprotective effectsen
dc.subjectendogenous sulfhydrylsen
dc.subjectnitric oxideen
dc.titleGastroprotective effect of Cissus sicyoides (Vitaceae): Involvement of microcirculation, endogenous sulfhydryls and nitric oxideen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1697547325096457
unesp.author.lattes5569977655658319[4]
unesp.author.lattes3814504901386844[8]
unesp.author.orcid0000-0002-8645-3777[8]
unesp.author.orcid0000-0003-3032-2556[7]
unesp.author.orcid0000-0002-0213-8551[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências, Baurupt
unesp.departmentCiências Biológicas - FCpt

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Artigos - Fisiologia - IBB
Artigos - Farmacologia - IBB
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