Plasma and Peritoneal Ceftriaxone Concentrations After Intraperitoneal Administration in Horses With Septic Peritonitis

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dc.contributor.authorAlonso, Juliana de M. [UNESP]
dc.contributor.authorMartins, Evelin S. [UNESP]
dc.contributor.authorPeccinini, Rosangela G. [UNESP]
dc.contributor.authorRosa, Gustavo S. [UNESP]
dc.contributor.authorGuerra, Simony T. [UNESP]
dc.contributor.authorRibeiro, Márcio G. [UNESP]
dc.contributor.authorSantos, Bruna [UNESP]
dc.contributor.authorGarcía, Henry D.M. [UNESP]
dc.contributor.authorWatanabe, Marcos J. [UNESP]
dc.contributor.authorTakahira, Regina K. [UNESP]
dc.contributor.authorRodrigues, Celso A. [UNESP]
dc.contributor.authorAlves, Ana Liz G. [UNESP]
dc.contributor.authorHussni, Carlos A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-06-25T10:44:23Z
dc.date.available2021-06-25T10:44:23Z
dc.date.issued2021-01-01
dc.description.abstractIntraperitoneal ceftriaxone administration in healthy horses results in high and prolonged peritoneal concentrations. Recent findings suggest that intraperitoneal ceftriaxone might increase survival rates in horses affected by peritonitis. The present study aimed to evaluate plasma and peritoneal concentrations of ceftriaxone after intraperitoneal administration in horses with septic peritonitis. Twenty-six horses presenting clinical, laboratorial, and sonographic findings compatible with the disease were included. All horses received daily intraperitoneal ceftriaxone (25 mg/kg bwt) in addition or not with other antibiotics and support therapies. High-performance liquid chromatography was used to determine plasma and peritoneal ceftriaxone concentrations before and after 12 and 24 hours of ceftriaxone administration. Mean plasma concentrations 12 and 24 hours after administration were, respectively, 1.84 ± 0.43 and 0.37 ± 0.07 μg/mL, and mean peritoneal concentrations were 5.7 ± 2.84 and 0.42 ± 0.13 μg/mL. Ceftriaxone concentration was lower in comparison with previous studies in healthy horses and presented under the minimal inhibitory concentration for enterobacteria (≤1 μg/mL) and for gram-positive isolates (≤0.5 μg/mL) at 24 hours. The variation of the results obtained between healthy horses and with septic peritonitis demonstrated that pharmacokinetics/dynamics are different between these patients and suggests the use of an interval of dose of 12 hours.en
dc.description.affiliationDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science Univ. Estadual Paulista (Unesp)
dc.description.affiliationDepartment of Natural Active Principles and Toxicology School of Pharmaceutical Sciences Univ. Estadual Paulista (Unesp)
dc.description.affiliationDepartment of Animal Production and Preventive Veterinary Medicine School of Veterinary Medicine and Animal Science Univ. Estadual Paulista (Unesp)
dc.description.affiliationDepartment of Veterinary Clinics School of Veterinary Medicine and Animal Science Univ. Estadual Paulista (Unesp)
dc.description.affiliationUnespDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science Univ. Estadual Paulista (Unesp)
dc.description.affiliationUnespDepartment of Natural Active Principles and Toxicology School of Pharmaceutical Sciences Univ. Estadual Paulista (Unesp)
dc.description.affiliationUnespDepartment of Animal Production and Preventive Veterinary Medicine School of Veterinary Medicine and Animal Science Univ. Estadual Paulista (Unesp)
dc.description.affiliationUnespDepartment of Veterinary Clinics School of Veterinary Medicine and Animal Science Univ. Estadual Paulista (Unesp)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: # 2016/08713-8
dc.identifierhttp://dx.doi.org/10.1016/j.jevs.2020.103310
dc.identifier.citationJournal of Equine Veterinary Science, v. 96.
dc.identifier.doi10.1016/j.jevs.2020.103310
dc.identifier.issn0737-0806
dc.identifier.scopus2-s2.0-85095946995
dc.identifier.urihttp://hdl.handle.net/11449/206819
dc.language.isoeng
dc.relation.ispartofJournal of Equine Veterinary Science
dc.sourceScopus
dc.subjectAbdominal infection
dc.subjectHPLC
dc.subjectMIC
dc.subjectPeritoneum
dc.titlePlasma and Peritoneal Ceftriaxone Concentrations After Intraperitoneal Administration in Horses With Septic Peritonitisen
dc.typeArtigo
unesp.author.orcid0000-0002-8664-5963[1]
unesp.author.orcid0000-0002-4837-463X[11]
unesp.departmentPrincípios Ativos Naturais e Toxicologia - FCFpt

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Artigos - Reprodução Animal e Radiologia Veterinária - FMVZ
Araraquara - FCF - Faculdade de Ciências Farmacêuticas
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Artigos - Produção Animal - FMVZ