Expression and imprinting of insulin-like growth factor II (IGF2) and H19 genes in uterine leiomyomas

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dc.contributor.authorRainho, C. A.
dc.contributor.authorPontes, Anaglória [UNESP]
dc.contributor.authorRogatto, Silvia Regina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:35:05Z
dc.date.available2014-05-20T13:35:05Z
dc.date.issued1999-09-01
dc.description.abstractGenomic imprinting is defined as a gamete of origin-specific epigenetic modification of DNA leading to differential gene expression in the zygote. Several imprinted genes have been identified and some of them are associated with tumor development. We investigated the expression and the imprinting status of IGF2 and H19 genes in 47 uterine leiomyomas. Using allelic transcription assay, we detected the expression of the IGF2 gene in 10 of a total of 15 informative cases. No loss of imprinting, as determined by the finding of biallelic expression, was detected in any case. The expression of H19 gene was detected in 10 of 20 informative cases and the imprinting pattern was also maintained in all of them. Our data suggest that alterations in IGF2 and H19 genes expression by loss of imprinting do not occur in uterine leiomyomas. (C) 1999 Academic Press.en
dc.description.affiliationUNESP, IB, Dept Genet, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUNESP, FMB, HC, Dept Obstet & Gynecol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, IB, Dept Genet, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, FMB, HC, Dept Obstet & Gynecol, BR-18618000 Botucatu, SP, Brazil
dc.format.extent375-380
dc.identifierhttp://dx.doi.org/10.1006/gyno.1999.5483
dc.identifier.citationGynecologic Oncology. San Diego: Academic Press Inc., v. 74, n. 3, p. 375-380, 1999.
dc.identifier.doi10.1006/gyno.1999.5483
dc.identifier.issn0090-8258
dc.identifier.lattes8814823545159504
dc.identifier.lattes0514178654667684
dc.identifier.lattes2259986546265579
dc.identifier.orcid0000-0002-0285-1162
dc.identifier.urihttp://hdl.handle.net/11449/12047
dc.identifier.wosWOS:000082708100009
dc.language.isoeng
dc.publisherAcademic Press Inc.
dc.relation.ispartofGynecologic Oncology
dc.relation.ispartofjcr4.540
dc.relation.ispartofsjr2,339
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectgenomic imprintingpt
dc.subjectgrowth factorpt
dc.subjectuterine tumorspt
dc.titleExpression and imprinting of insulin-like growth factor II (IGF2) and H19 genes in uterine leiomyomasen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderAcademic Press Inc.
unesp.author.lattes0514178654667684
unesp.author.lattes2259986546265579
unesp.author.lattes8814823545159504[1]
unesp.author.orcid0000-0002-0285-1162[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Genética - IBB
Artigos - Ginecologia e Obstetrícia - FMB