Pilot study of homologous platelet gel in venous ulcers

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dc.contributor.authorde Oliveira, Mariele Gobo [UNESP]
dc.contributor.authorAbbade, Luciana Patricia Fernandes [UNESP]
dc.contributor.authorMiot, Hélio Amante [UNESP]
dc.contributor.authorFerreira, Rosana Rossi [UNESP]
dc.contributor.authorDeffune, Elenice [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:14:59Z
dc.date.available2018-12-11T17:14:59Z
dc.date.issued2017-07-01
dc.description.abstractBackground: Venous ulcers represent 70% of the lower limb ulcers. They are difficult to heal, requiring a correct diagnostic and therapeutic approach. Many products have been developed to healing, such as homologous platelet gel obtained from the platelet concentrate exceeding from blood transfusion. Objective: To evaluate the safety and efficacy of homologous platelet gel in venous ulcers compared with hydrocolloid dressing. Method: A pilot randomized clinical trial in patients with venous ulcers. Randomized groups (homologous platelet gel and hydrocolloid groups) were followed for 90 days and were assessed through the evolution of ulcerated area, qualitative analysis of vascularization and adverse events. Both groups used elastic compression. Results: We included 16 participants, with a total of 21 venous ulcers. Both treatments promoted a reduction of the areas of the ulcers in 90 days (mean 69%), there was significant difference between the groups concerning the gradual reduction of the ulcers areas, favorably to the hydrocolloid (70% vs 64%; p <0.01). There were some mild adverse events in both groups. Study limitations: Single-center study with a small number of patients, preventing more accurate assessment of the effects of platelet gel. Conclusion: The homologous platelet gel associated with the elastic compression can be an alternative to the venous ulcer treatment and is safe due to the occurrence of a few mild local adverse events and no serious adverse events. Clinical trials with larger numbers of patients must be performed to maintain the indication of this treatment for venous ulcer.en
dc.description.affiliationDepartment of Nursing Botucatu Medical School São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)
dc.description.affiliationDepartment of Dermatology and Radiotherapy Botucatu Medical School São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)
dc.description.affiliationDepartment of Biological Sciences Faculty of Sciences of Bauru São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)
dc.description.affiliationCellular Engineering Laboratory Botucatu Medical School São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)
dc.description.affiliationUnespDepartment of Nursing Botucatu Medical School São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)
dc.description.affiliationUnespDepartment of Dermatology and Radiotherapy Botucatu Medical School São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)
dc.description.affiliationUnespDepartment of Biological Sciences Faculty of Sciences of Bauru São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)
dc.description.affiliationUnespCellular Engineering Laboratory Botucatu Medical School São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2009/03559-3
dc.format.extent499-504
dc.identifierhttp://dx.doi.org/10.1590/abd1806-4841.20175496
dc.identifier.citationAnais Brasileiros de Dermatologia, v. 92, n. 4, p. 499-504, 2017.
dc.identifier.doi10.1590/abd1806-4841.20175496
dc.identifier.fileS0365-05962017000400499.pdf
dc.identifier.issn1806-4841
dc.identifier.issn0365-0596
dc.identifier.lattes8084974543029515
dc.identifier.scieloS0365-05962017000400499
dc.identifier.scopus2-s2.0-85029825717
dc.identifier.urihttp://hdl.handle.net/11449/175245
dc.language.isoeng
dc.relation.ispartofAnais Brasileiros de Dermatologia
dc.relation.ispartofsjr0,520
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectHydrocolloid bandages
dc.subjectPlatelet-rich plasma
dc.subjectVaricose ulcer
dc.subjectWound healing
dc.titlePilot study of homologous platelet gel in venous ulcersen
dc.typeArtigo
unesp.author.lattes8084974543029515
unesp.departmentCiências Biológicas - FCpt

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Artigos - Enfermagem - FMB
Artigos - Dermatologia e Radioterapia - FMB
Bauru - FC - Faculdade de Ciências