Integration of nutrigenomics, melatonin, serotonin and inflammatory cytokines in the pathophysiology of pregnancy-specific urinary incontinence in women with gestational diabetes mellitus

dc.contributor.authorFrança, Danielle Cristina Honorio [UNESP]
dc.contributor.authorFrança, Eduardo Luzía
dc.contributor.authorSobrevia, Luis [UNESP]
dc.contributor.authorBarbosa, Angélica Mércia Pascon [UNESP]
dc.contributor.authorHonorio-França, Adenilda Cristina
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFederal University of Mato Grosso (UFMT)
dc.contributor.institutionPontificia Universidad Católica de Chile
dc.contributor.institutionUniversidad de Sevilla
dc.contributor.institutionUniversity of Queensland
dc.contributor.institutionUniversity of Groningen
dc.contributor.institutionSchool of Medicine and Health Sciences
dc.date.accessioned2023-07-29T13:54:06Z
dc.date.available2023-07-29T13:54:06Z
dc.date.issued2023-08-01
dc.description.abstractGestational diabetes mellitus is an important public health problem and has been associated with the development of pregnancy-specific urinary incontinence. The interaction is related to hyperglycemia, and inflammatory and hormonal patterns, which favor functional alterations in different organs and systems. Several genes associated with human diseases have been identified and partially characterized. Most of these genes are known to cause monogenic diseases. However, about 3 % of diseases do not fit the monogenic theory due to the complex interactions between multiple genes and environmental factors, as in chronic metabolic diseases such as diabetes. The nutritional, immunological, and hormonal patterns associated with changes in maternal metabolism may influence and contribute to greater susceptibility to urinary tract disorders. However, early systematic reviews have not yielded consistent findings for these associations. This literature review summarizes important new findings from integrating nutrigenomics, hormones, and cytokines in women with Gestational diabetes mellitus and pregnancy-specific urinary incontinence. Changes in maternal metabolism due to hyperglycemia can generate an inflammatory environment with increased inflammatory cytokines. This environment modulated by inflammation can alter tryptophan uptake through food and thus influence the production of serotonin and melatonin. As these hormones seem to have protective effects against smooth muscle dysfunction and to restore the impaired contractility of the detrusor muscle, it is assumed that these changes may favor the onset of urinary incontinence specific to pregnancy.en
dc.description.affiliationDepartment of Gynecology and Obstetrics Botucatu Medical School (FMB) São Paulo State University (UNESP)
dc.description.affiliationInstitute of Biological and Health Science Federal University of Mato Grosso (UFMT)
dc.description.affiliationCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile
dc.description.affiliationDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla
dc.description.affiliationFaculty of Medicine and Biomedical Sciences University of Queensland
dc.description.affiliationDepartment of Pathology and Medical Biology University of Groningen
dc.description.affiliationTecnologico de Monterrey Eutra The Institute for Obesity Research (IOR) School of Medicine and Health Sciences
dc.description.affiliationDepartment of Physiotherapy and Occupational Therapy School of Philosophy and Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Gynecology and Obstetrics Botucatu Medical School (FMB) São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Physiotherapy and Occupational Therapy School of Philosophy and Sciences São Paulo State University (UNESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipPontificia Universidad Católica de Chile
dc.description.sponsorshipUniversidade Estadual Paulista
dc.description.sponsorshipFondo Nacional de Desarrollo Científico y Tecnológico
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFondo Nacional de Desarrollo Científico y Tecnológico: 1190316
dc.description.sponsorshipIdFAPESP: 2016/01743–5
dc.description.sponsorshipIdCNPq: 305116/2018-5
dc.identifierhttp://dx.doi.org/10.1016/j.bbadis.2023.166737
dc.identifier.citationBiochimica et Biophysica Acta - Molecular Basis of Disease, v. 1869, n. 6, 2023.
dc.identifier.doi10.1016/j.bbadis.2023.166737
dc.identifier.issn1879-260X
dc.identifier.issn0925-4439
dc.identifier.scopus2-s2.0-85158873676
dc.identifier.urihttp://hdl.handle.net/11449/248800
dc.language.isoeng
dc.relation.ispartofBiochimica et Biophysica Acta - Molecular Basis of Disease
dc.sourceScopus
dc.subjectEpigenetic
dc.subjectHormones
dc.subjectHyperglycemia
dc.subjectImmunomodulation
dc.subjectInvoluntary loss of urine
dc.titleIntegration of nutrigenomics, melatonin, serotonin and inflammatory cytokines in the pathophysiology of pregnancy-specific urinary incontinence in women with gestational diabetes mellitusen
dc.typeResenha
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Filosofia e Ciências, Maríliapt
unesp.departmentFisioterapia e Terapia Ocupacional - FFCpt

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