Quercetin reduces Staphylococcus aureus interaction with neutrophils
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2011-09-01
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Flavonoids, including quercetin, have been reported to modulate the ability of Staphylococcus aureus to adhere to host tissue without exhibiting direct antibacterial activity. In the present study, we evaluated the interaction of S. aureus pretreated with 40 μg/mL of quercetin with neutrophils to assay oxidative burst stimulation, using luminol-amplified chemiluminescence. S. aureus pre-incubated with subinhibitory concentration of quercetin induced significantly less light emission by neutrophils than did untreated bacteria. The results of the present study demonstrate that quercetin decreases S. aureus uptake by neutrophils.
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Neutrophils, Oxidative burst, Quercetin, Staphylococcus aureus, quercetin, animal cell, antibacterial activity, bacterial cell, bacterium adherence, cell surface, cell viability, chemoluminescence, controlled study, drug determination, drug mechanism, minimum inhibitory concentration, molecular dynamics, molecular interaction, neutrophil, nonhuman, rat, respiratory burst
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International Journal of Pharmacognosy and Phytochemical Research, v. 3, n. 3, p. 85-88, 2011.