Quercetin reduces Staphylococcus aureus interaction with neutrophils

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dc.contributor.authorCamargo, M. S. [UNESP]
dc.contributor.authorBonacorsi, C. [UNESP]
dc.contributor.authorKitagawa, R. R.
dc.contributor.authorFonseca, Luiz Marcos da [UNESP]
dc.contributor.authorRaddi, Maria Stella Gonçalves [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Espírito Santo (UFES)
dc.date.accessioned2014-05-27T11:25:59Z
dc.date.available2014-05-27T11:25:59Z
dc.date.issued2011-09-01
dc.description.abstractFlavonoids, including quercetin, have been reported to modulate the ability of Staphylococcus aureus to adhere to host tissue without exhibiting direct antibacterial activity. In the present study, we evaluated the interaction of S. aureus pretreated with 40 μg/mL of quercetin with neutrophils to assay oxidative burst stimulation, using luminol-amplified chemiluminescence. S. aureus pre-incubated with subinhibitory concentration of quercetin induced significantly less light emission by neutrophils than did untreated bacteria. The results of the present study demonstrate that quercetin decreases S. aureus uptake by neutrophils.en
dc.description.affiliationFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista-UNESP, Araraquara, SP
dc.description.affiliationDepartamento de Ciências Farmacêuticas Universidade Federal do Espírito Santo, Vitória, ES
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista-UNESP, Araraquara, SP
dc.format.extent85-88
dc.identifierhttp://www.ijppr.com/PDF%20all%20edtions%20IJPPR/Vol3/Issue3/IJPPR,Vol3,Issue3,Article9.pdf
dc.identifier.citationInternational Journal of Pharmacognosy and Phytochemical Research, v. 3, n. 3, p. 85-88, 2011.
dc.identifier.issn0975-4873
dc.identifier.lattes4419635633356792
dc.identifier.scopus2-s2.0-80455127333
dc.identifier.urihttp://hdl.handle.net/11449/72652
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmacognosy and Phytochemical Research
dc.relation.ispartofsjr0,116
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectNeutrophils
dc.subjectOxidative burst
dc.subjectQuercetin
dc.subjectStaphylococcus aureus
dc.subjectquercetin
dc.subjectanimal cell
dc.subjectantibacterial activity
dc.subjectbacterial cell
dc.subjectbacterium adherence
dc.subjectcell surface
dc.subjectcell viability
dc.subjectchemoluminescence
dc.subjectcontrolled study
dc.subjectdrug determination
dc.subjectdrug mechanism
dc.subjectminimum inhibitory concentration
dc.subjectmolecular dynamics
dc.subjectmolecular interaction
dc.subjectneutrophil
dc.subjectnonhuman
dc.subjectrat
dc.subjectrespiratory burst
dc.titleQuercetin reduces Staphylococcus aureus interaction with neutrophilsen
dc.typeArtigo
unesp.author.lattes4419635633356792
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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