Effects of a Biocomplex Formed by Two Scaffold Biomaterials, Hydroxyapatite/Tricalcium Phosphate Ceramic and Fibrin Biopolymer, with Photobiomodulation, on Bone Repair

Página do item simplificado
dc.contributor.authorReis, Carlos Henrique Bertoni
dc.contributor.authorBuchaim, Rogerio Leone
dc.contributor.authorPomini, Karina Torres
dc.contributor.authorHamzé, Abdul Latif
dc.contributor.authorZattiti, Isabella Vasconcelos
dc.contributor.authorDuarte, Marco Antonio Hungaro
dc.contributor.authorAlcalde, Murilo Priori
dc.contributor.authorBarraviera, Benedito [UNESP]
dc.contributor.authorFerreira Júnior, Rui Seabra [UNESP]
dc.contributor.authorPontes, Fenelon Martinho Lima [UNESP]
dc.contributor.authorGrandini, Carlos Roberto [UNESP]
dc.contributor.authorOrtiz, Adriana de Cássia
dc.contributor.authorFideles, Simone Ortiz Moura
dc.contributor.authorEugênio, Renata Maria de Camargo
dc.contributor.authorRosa Junior, Geraldo Marco
dc.contributor.authorTeixeira, Daniel de Bortoli
dc.contributor.authorPereira, Eliana de Souza Bastos Mazuqueli
dc.contributor.authorPilon, João Paulo Galletti [UNESP]
dc.contributor.authorMiglino, Maria Angelica
dc.contributor.authorBuchaim, Daniela Vieira
dc.contributor.institutionUniversity of Marilia (UNIMAR)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUnisagrado University Center
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFIASP
dc.contributor.institutionUniversity Center of Adamantina (UniFAI)
dc.date.accessioned2023-03-01T20:43:55Z
dc.date.available2023-03-01T20:43:55Z
dc.date.issued2022-05-01
dc.description.abstractThere are several treatment methods available for bone repair, although the effectiveness becomes limited in cases of large defects. The objective of this pre-clinical protocol was to evalu-ate the grafting of hydroxyapatite/tricalcium phosphate (BCP) ceramic biomaterial (B; QualyBone BCP®, QualyLive, Amadora, Portugal) together with the heterologous fibrin biopolymer (FB; CE-VAP/UNESP Botucatu, Brazil) and with photobiomodulation (PBM; Laserpulse®, Ibramed, Amparo, Brazil) in the repair process of bone defects. Fifty-six rats were randomly divided into four groups of seven animals each: the biomaterial group (G1/B), the biomaterial plus FB group (G2/BFB); the bioma-terial plus PBM group (G3/B + PBM), and the biomaterial plus FB plus PBM group (G4/BFB + PBM). After anesthesia, a critical defect was performed in the center of the rats’ parietal bones, then filled and treated according to their respective groups. The rats were euthanized at 14 and 42 postopera-tive days. Histomorphologically, at 42 days, the G4/BFB + PBM group showed a more advanced maturation transition, with more organized and mature bone areas forming concentric lamellae. A birefringence analysis of collagen fibers also showed a more advanced degree of maturation for the G4/BFB + PBM group. In the comparison between the groups, in the two experimental periods (14 and 42 days), in relation to the percentage of formation of new bone tissue, a significant difference was found between all groups (G1/B (5.42 ± 1.12; 21.49 ± 4.74), G2/BFB (5.00 ± 0.94; 21.77 ± 2.83), G3/B + PBM (12.65 ± 1.78; 29.29 ± 2.93), and G4/BFB + PBM (12.65 ± 2.32; 31.38 ± 2.89)). It was concluded that the use of PBM with low-level laser therapy (LLLT) positively interfered in the repair process of bone defects previously filled with the biocomplex formed by the heterologous fibrin biopolymer associated with the synthetic ceramic of hydroxyapatite and tricalcium phosphate.en
dc.description.affiliationUNIMAR Beneficent Hospital (HBU) University of Marilia (UNIMAR)
dc.description.affiliationDepartment of Biological Sciences Bauru School of Dentistry (FOB/USP) University of São Paulo
dc.description.affiliationGraduate Program in Anatomy of Domestic and Wild Animals Faculty of Veterinary Medicine and Animal Science University of São Paulo (FMVZ/USP)
dc.description.affiliationPostgraduate Program in Structural and Functional Interactions in Rehabilitation Postgraduate Department University of Marilia (UNIMAR)
dc.description.affiliationMedical School University of Marilia (UNIMAR)
dc.description.affiliationDepartment of Dentistry Endodontics and Dental Materials Bauru School of Dentistry University of São Paulo (FOB/USP)
dc.description.affiliationDepartment of Health Science Unisagrado University Center
dc.description.affiliationCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (Univ Estadual Paulista UNESP)
dc.description.affiliationGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP–Univ Estadual Paulista)
dc.description.affiliationChemistry Department Faculty of Science São Paulo State University (UNESP–Univ Estadual Paulista)
dc.description.affiliationLaboratório de Anelasticidade e Biomateriais Physics Department Faculty of Science São Paulo State University (UNESP–Univ Estadual Paulista)
dc.description.affiliationFaculdade Ibero Americana de São Paulo FIASP
dc.description.affiliationPostgraduate Program in Animal Health Production and Environment University of Marilia (UNIMAR)
dc.description.affiliationPostgraduate Program in Speech Therapy Sao Paulo State University (UNESP—Univ Estadual Paulista)
dc.description.affiliationTeaching and Research Coordination of the Medical School University Center of Adamantina (UniFAI)
dc.description.affiliationUnespCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (Univ Estadual Paulista UNESP)
dc.description.affiliationUnespGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP–Univ Estadual Paulista)
dc.description.affiliationUnespChemistry Department Faculty of Science São Paulo State University (UNESP–Univ Estadual Paulista)
dc.description.affiliationUnespLaboratório de Anelasticidade e Biomateriais Physics Department Faculty of Science São Paulo State University (UNESP–Univ Estadual Paulista)
dc.description.affiliationUnespPostgraduate Program in Speech Therapy Sao Paulo State University (UNESP—Univ Estadual Paulista)
dc.identifierhttp://dx.doi.org/10.3390/polym14102075
dc.identifier.citationPolymers, v. 14, n. 10, 2022.
dc.identifier.doi10.3390/polym14102075
dc.identifier.issn2073-4360
dc.identifier.scopus2-s2.0-85130564834
dc.identifier.urihttp://hdl.handle.net/11449/241029
dc.language.isoeng
dc.relation.ispartofPolymers
dc.sourceScopus
dc.subjectbiomaterials
dc.subjectbone regeneration
dc.subjectbone repair
dc.subjectfibrin
dc.subjectfibrin tissue adhesive
dc.subjectlow-level laser therapy
dc.subjectphotobiomodulation
dc.titleEffects of a Biocomplex Formed by Two Scaffold Biomaterials, Hydroxyapatite/Tricalcium Phosphate Ceramic and Fibrin Biopolymer, with Photobiomodulation, on Bone Repairen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Filosofia e Ciências, Maríliapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentFonoaudiologia - FFCpt
unesp.departmentDoenças Tropicais e Diagnósticos por Imagem - FMBpt

Arquivos

Coleções

Botucatu - CEVAP - Centro de Estudos de Venenos e Animais Peçonhentos
Botucatu - FMB - Faculdade de Medicina
Marília - FFC - Faculdade de Filosofia e Ciências