Influence of Dorper lamb development from birth to 120 days of age on clinical and echocardiographic parameters

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dc.contributor.authorAleixo, Amanda Sarita Cruz [UNESP]
dc.contributor.authorFerreira, Danilo Otávio Laurenti
dc.contributor.authorTsunemi, Miriam Harumi [UNESP]
dc.contributor.authorChiacchio, Simone Biagio [UNESP]
dc.contributor.authorLourenço, Maria Lucia Gomes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionOffice of Agricultural Defense of Bauru - EDA
dc.date.accessioned2023-07-29T15:14:40Z
dc.date.available2023-07-29T15:14:40Z
dc.date.issued2022-12-01
dc.description.abstractThe expansion of the sheep model in research represents an attractive and economically beneficial academic reason for investigations in sheep echocardiography. The present study aimed to evaluate the clinical and echocardiographic parameters in Dorper lambs during the developmental period. Emphasis was placed on the use of the species in translational research for the echocardiographic diagnosis of congenital heart diseases, which can contribute to improvements in interventionist techniques. Ten Dorper lambs were evaluated at the following time points: 24 h after birth and 7, 14, 21, 30, 60, 90 and 120 days of age. Clinical parameters were compiled, and echocardiogram records were obtained without sedation. Rectal temperature was lower on the first day compared to the others. From 21 days of life, there was a reduction in HR, with differences between time points. Mean and systolic blood pressure differed, with the highest values at 90 and 120 days of age. The thickness of the interventricular septum in diastole (IVSd) increased as age progressed, with the highest value at 120 days of age, and the same occurred for LVIDd (left ventricle internal diameter in diastole), LVFWd (left ventricular free wall thickness in diastole), IVSs (interventricular septum thickness in systole), LVIDs (left ventricle internal diameter in systole) and LVFWs (left ventricular free wall thickness in systole). There were differences in the size of the LA, Ao and LA/Ao ratio, which were greater at 90 days and 120 days of age. Echocardiographic changes accompany the development of lambs, where changes in echocardiographic parameters are evident with advancing age. The echocardiographic measurements in lambs obtained in the present study are similar to those in newborns.en
dc.description.affiliationSchool of Veterinary Medicine and Animal Science São Paulo State University (Unesp), São Paulo
dc.description.affiliationSecretary of Agriculture and Supply of the State of São Paulo - SAA/SP Coordination of Agricultural Defense - CDA Office of Agricultural Defense of Bauru - EDA
dc.description.affiliationInstitute of Biosciences São Paulo State University (Unesp), São Paulo
dc.description.affiliationSchool of Veterinary Medicine and Animal Science São Paulo State University (Unesp) Rua Prof. Doutor Walter Mauricio Correa, São Paulo, S/N Bairro: Unesp Campus de Botucatu
dc.description.affiliationUnespSchool of Veterinary Medicine and Animal Science São Paulo State University (Unesp), São Paulo
dc.description.affiliationUnespInstitute of Biosciences São Paulo State University (Unesp), São Paulo
dc.description.affiliationUnespSchool of Veterinary Medicine and Animal Science São Paulo State University (Unesp) Rua Prof. Doutor Walter Mauricio Correa, São Paulo, S/N Bairro: Unesp Campus de Botucatu
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2017/15121-9
dc.identifierhttp://dx.doi.org/10.1038/s41598-022-23418-z
dc.identifier.citationScientific Reports, v. 12, n. 1, 2022.
dc.identifier.doi10.1038/s41598-022-23418-z
dc.identifier.issn2045-2322
dc.identifier.scopus2-s2.0-85142165335
dc.identifier.urihttp://hdl.handle.net/11449/249384
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.sourceScopus
dc.titleInfluence of Dorper lamb development from birth to 120 days of age on clinical and echocardiographic parametersen
dc.typeArtigo

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Artigos - Bioestatística - IBB
Artigos - Clínica Veterinária - FMVZ