Publicação: Perfusão cerebral e análise individual automatizada utilizando SPECT em uma população com transtorno obsessivo-compulsivo
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Objective: To make individual assessments using automated quantification methodology in order to screen for perfusion abnormalities in cerebral SPECT examinations among a sample of subjects with OCD. Methods: Statistical parametric mapping (SPM) was used to compare 26 brain SPECT images from patients with OCD individually with an image bank of 32 normal subjects, using the statistical threshold of p < 0.05 (corrected for multiple comparisons at the level of individual voxels or clusters). The maps were analyzed, and regions presenting voxels that remained above this threshold were sought. results: Six patients from a sample of 26 OCD images showed abnormalities at cluster or voxel level, considering the criteria described above, which represented 23.07%. However, seven images from the normal group of 32 were also indicated as cases of perfusional abnormality, representing 21.8% of the sample. Conclusion: The automated quantification method was not considered to be a useful tool for clinical practice, for analyses complementary to visual inspection.
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Brain SPECT, Individual analysis, OCD, SPM, cysteine ethyl ester tc 99m, adult, automation, brain mapping, brain perfusion, clinical article, clinical assessment, controlled study, female, human, image processing, male, obsessive compulsive disorder, prediction, single photon emission computer tomography
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Português
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Jornal Brasileiro de Psiquiatria, v. 60, n. 1, p. 1-6, 2011.
