Extracellular matrix in ocular homeostasis and diseases: The heroes, the villains, and the magic

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dc.contributor.authorAldrovani, Marcela [UNESP]
dc.contributor.authorCristovam, Priscila Cardoso
dc.contributor.authorPascoli, Ana Lúcia [UNESP]
dc.contributor.authorda Silva, Germana Alegro [UNESP]
dc.contributor.authorMadruga, Gabriela Morais [UNESP]
dc.contributor.authorBandeira e Silva, Francisco
dc.contributor.authorLaus, José Luiz [UNESP]
dc.contributor.institutionUniversity of Franca
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionSão Paulo Federal University
dc.contributor.institutionRegional University of Blumenau
dc.date.accessioned2022-04-30T14:09:25Z
dc.date.available2022-04-30T14:09:25Z
dc.date.issued2018-08-09
dc.description.abstractThe eyes are highly diversified photosensitive structures. In all vertebrates, eyes resemble in molecular composition and are predominantly composed of extracellular matrix (ECM). Compared with other structures, the eyes have ECM in unique arrangements. Because the ocular ECM is labile and dynamic, when remodeling, it may lead to a series of diseases or alterations that impair vision. Post-translational processing of ECM molecules of the eye can be impaired by multiple multifactorial conditions that trigger the onset of ocular diseases, including corneal dystrophies, glaucoma, macular degeneration, and tumors. Besides, the ECM is the link that connects the eyes to other structures of the body, so a variety of systemic hereditary or autoimmune connective tissue disorders can affect the ocular homeostasis. This work explores the dual role (from hero to a villain) of ECM in ocular homeostasis and diseases and discusses how this duality can be magically used to treat ocular diseases. The view on ECM biology offered by this work is translational and address concepts of basic science and clinicalsurgical issues.en
dc.description.affiliationUniversity of Franca
dc.description.affiliationDepartment of Veterinary Clinics and Surgery São Paulo State University
dc.description.affiliationDepartment of Opthalmology and Visual Sciences São Paulo Federal University
dc.description.affiliationCollege of Veterinary Medicine Regional University of Blumenau
dc.description.affiliationUnespDepartment of Veterinary Clinics and Surgery São Paulo State University
dc.format.extent1-104
dc.identifier.citationAdvances in Medicine and Biology, p. 1-104.
dc.identifier.scopus2-s2.0-85058908572
dc.identifier.urihttp://hdl.handle.net/11449/232840
dc.language.isoeng
dc.relation.ispartofAdvances in Medicine and Biology
dc.sourceScopus
dc.subjectEye
dc.subjectMatrix remodeling
dc.subjectOphthalmic disorders
dc.subjectRegenerative medicine
dc.titleExtracellular matrix in ocular homeostasis and diseases: The heroes, the villains, and the magicen
dc.typeCapítulo de livro
unesp.departmentClínica e Cirurgia Veterinária - FCAVpt

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Jaboticabal - FCAV - Faculdade de Ciências Agrárias e Veterinárias