Effect of DOPA and dopamine coupling on protein loading of hydroxyapatite
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Data
2016-01-01
Autores
Kollath, V. Ozhukil [UNESP]
Mullens, S.
Luyten, J.
Traina, K.
Cloots, R.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Taylor & Francis Ltd
Resumo
Hydroxyapatite (HA) is a promising carrier material for oral delivery of biomolecules such as proteins and drugs. Ways to increase the loading of such molecules on HA will lead to better nanomedicine. This study reports the surface functionalisation of HA particles using the mussel inspired molecules dopamine (DA) and 3,4-dihydroxy-L-phenylalanine (DOPA), in order to increase protein loading. The adsorption mechanisms are discussed based on the adsorption isotherms, zeta potential, thermal analysis and theoretical models. Results show that DA functionalisation enhanced the loading, while DOPA functionalisation was ineffective.
Descrição
Palavras-chave
Hydroxyapatite, Protein, Dopamine, Adsorption isotherm, Oral delivery
Como citar
Materials Technology. Abingdon: Taylor & Francis Ltd, v. 31, n. 4, p. 241-245, 2016.