Detection of heterozygous MDR1 nt230(del4) mutation in a mixed-breed dog: case report of possible doxorubicin toxicosis
dc.contributor.author | Monobe, Marina Mitie [UNESP] | |
dc.contributor.author | Lunsford, Kari V. | |
dc.contributor.author | Araújo Júnior, João Pessoa [UNESP] | |
dc.contributor.author | Bulla, Camilo | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Mississippi State University | |
dc.date.accessioned | 2016-07-07T12:34:27Z | |
dc.date.available | 2016-07-07T12:34:27Z | |
dc.date.issued | 2013 | |
dc.description.abstract | P-glycoprotein (ABCB1), the product of the Multidrug Resistance Gene (MDR1) (ABCB1) gene, is the major multidrug transporter contributing to the barrier function of several tissues and organs, including the brain. A four base pair deletion mutation in MDR1 results in the absence of a functional form of ABCB1 and loss of its protective function. Severe intoxication with the ABCB1 substrate, such as with anticancer drugs, has been attributed to genetic lack of functional ABCB1. This mutation has been detected in more than 10 dog breeds as well as in mixed-breed dogs living in different countries. In Brazil, evaluation for this mutation is not as widely available and is rarely used by veterinarians, so drug intoxication may be underdiagnosed. This is the first report from Brazil of doxorubicin neurotoxicity in a mixed-breed dog with the MDR1 nt230(del4) mutation. | en |
dc.description.affiliation | Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Clínica Veterinária, Botucatu, SP, Brasil | |
dc.description.affiliation | Mississippi State University, MS, USA | |
dc.description.affiliation | Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Instituto de Biociências (IBB), Departamento de Microbiologia e Imunologia, Botucatu, SP, Brasil | |
dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Clínica Veterinária, Botucatu, SP, Brasil | |
dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Instituto de Biociências (IBB), Departamento de Microbiologia e Imunologia, Botucatu, SP, Brasil | |
dc.format.extent | 35-38 | |
dc.identifier | http://dx.doi.org/10.2147/VMRR.S41066 | |
dc.identifier.citation | Veterinary Medicine: Research and Reports, v. 4, p. 35-38, 2013. | |
dc.identifier.doi | 10.2147/VMRR.S41066 | |
dc.identifier.file | ISSN2230-2034-2013-04-35-38.pdf | |
dc.identifier.issn | 2230-2034 | |
dc.identifier.uri | http://hdl.handle.net/11449/140563 | |
dc.language.iso | eng | |
dc.relation.ispartof | Veterinary Medicine: Research and Reports | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Currículo Lattes | |
dc.subject | Canine | en |
dc.subject | Toxicology | en |
dc.subject | Cancer | en |
dc.subject | P-glycoprotein | en |
dc.title | Detection of heterozygous MDR1 nt230(del4) mutation in a mixed-breed dog: case report of possible doxorubicin toxicosis | en |
dc.type | Artigo | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatu | pt |
unesp.campus | Universidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatu | pt |
unesp.department | Clínica Veterinária | pt |
unesp.department | Microbiologia e Imunologia | pt |
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