Detection of heterozygous MDR1 nt230(del4) mutation in a mixed-breed dog: case report of possible doxorubicin toxicosis

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dc.contributor.authorMonobe, Marina Mitie [UNESP]
dc.contributor.authorLunsford, Kari V.
dc.contributor.authorAraújo Júnior, João Pessoa [UNESP]
dc.contributor.authorBulla, Camilo
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionMississippi State University
dc.date.accessioned2016-07-07T12:34:27Z
dc.date.available2016-07-07T12:34:27Z
dc.date.issued2013
dc.description.abstractP-glycoprotein (ABCB1), the product of the Multidrug Resistance Gene (MDR1) (ABCB1) gene, is the major multidrug transporter contributing to the barrier function of several tissues and organs, including the brain. A four base pair deletion mutation in MDR1 results in the absence of a functional form of ABCB1 and loss of its protective function. Severe intoxication with the ABCB1 substrate, such as with anticancer drugs, has been attributed to genetic lack of functional ABCB1. This mutation has been detected in more than 10 dog breeds as well as in mixed-breed dogs living in different countries. In Brazil, evaluation for this mutation is not as widely available and is rarely used by veterinarians, so drug intoxication may be underdiagnosed. This is the first report from Brazil of doxorubicin neurotoxicity in a mixed-breed dog with the MDR1 nt230(del4) mutation.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Clínica Veterinária, Botucatu, SP, Brasil
dc.description.affiliationMississippi State University, MS, USA
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Instituto de Biociências (IBB), Departamento de Microbiologia e Imunologia, Botucatu, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Clínica Veterinária, Botucatu, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Instituto de Biociências (IBB), Departamento de Microbiologia e Imunologia, Botucatu, SP, Brasil
dc.format.extent35-38
dc.identifierhttp://dx.doi.org/10.2147/VMRR.S41066
dc.identifier.citationVeterinary Medicine: Research and Reports, v. 4, p. 35-38, 2013.
dc.identifier.doi10.2147/VMRR.S41066
dc.identifier.fileISSN2230-2034-2013-04-35-38.pdf
dc.identifier.issn2230-2034
dc.identifier.urihttp://hdl.handle.net/11449/140563
dc.language.isoeng
dc.relation.ispartofVeterinary Medicine: Research and Reports
dc.rights.accessRightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectCanineen
dc.subjectToxicologyen
dc.subjectCanceren
dc.subjectP-glycoproteinen
dc.titleDetection of heterozygous MDR1 nt230(del4) mutation in a mixed-breed dog: case report of possible doxorubicin toxicosisen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.departmentClínica Veterináriapt
unesp.departmentMicrobiologia e Imunologiapt

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