Antibody and cytokine serum levels in patients subjected to anti-rabies prophylaxis with serum-vaccination

dc.contributor.authorAyres, Jairo Aparecido [UNESP]
dc.contributor.authorBarraviera, Benedito [UNESP]
dc.contributor.authorCalvi, Sueli Aparecida [UNESP]
dc.contributor.authorCarvalho, N. R. [UNESP]
dc.contributor.authorPeraçoli, Maria Terezinha Serrão [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:00Z
dc.date.available2014-05-27T11:22:00Z
dc.date.issued2006-10-05
dc.description.abstractRabies is considered a fatal disease once clinical symptoms have developed. The aim of this study was to evaluate epidemiological aspects and immune response in patients attacked by domestic and wild animals and subjected to post-exposure rabies treatment with equine serum and associated vaccine. Thirty-three patients were evaluated; they were between 13 and 65 years old, 75.8% were male and 24.2% female, and from the Botucatu neighborhood. Twenty healthy control individuals with the same age range were also studied. Specific antibodies to equine immunoglobulins and IFN-γ, IL-2, IL-4, and IL-10 production were evaluated by ELISA. IgM, IgE, IgG and subclasses, and rabies virus antibodies serum levels were determined by nephelometry and seroneutralization methods, respectively. No anaphylactic or serum sickness allergic reactions were observed in patients after treatment. Anti-equine IgG levels were significantly higher than those of IgM after 14 and 28 days of treatment. Protective antibodies to rabies virus > 0.5 UI/ml were detected in 84.6% and 75% of patients at days 14 and 28, respectively. IFN-γ, IL-2 and IL-10 levels in patients before and 48h after treatment were significantly higher than in controls suggesting that both Th1 and Th2 cells were activated in the patients. Serum IgM levels were higher at day 14, and IgG 2 and IgE levels were higher at day 28 of treatment. These results suggest that post-exposure rabies treatment in humans induces significant alterations in patient immune response characterized by increased levels of cytokines, serum levels of specific rabies virus antibodies, and the equine serum components employed in the treatment.en
dc.description.affiliationDepartment of Nursing São Paulo State University UNESP, Botucatu, São Paulo State
dc.description.affiliationDepartment of Tropical Diseases and Imaging Diagnosis São Paulo State University UNESP, Botucatu, São Paulo State
dc.description.affiliationUniversity Hospital São Paulo State University UNESP, Botucatu, São Paulo State
dc.description.affiliationDepartment of Microbiology and Immunology São Paulo State University UNESP, Botucatu, São Paulo State
dc.description.affiliationDepartamento de Enfermagem Faculdade de Medicina de Botucatu UNESP, Distrito de Rubião Jr., 18618-000, Botucatu, SP
dc.description.affiliationUnespDepartment of Nursing São Paulo State University UNESP, Botucatu, São Paulo State
dc.description.affiliationUnespDepartment of Tropical Diseases and Imaging Diagnosis São Paulo State University UNESP, Botucatu, São Paulo State
dc.description.affiliationUnespUniversity Hospital São Paulo State University UNESP, Botucatu, São Paulo State
dc.description.affiliationUnespDepartment of Microbiology and Immunology São Paulo State University UNESP, Botucatu, São Paulo State
dc.description.affiliationUnespDepartamento de Enfermagem Faculdade de Medicina de Botucatu UNESP, Distrito de Rubião Jr., 18618-000, Botucatu, SP
dc.format.extent435-455
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992006000300008
dc.identifier.citationJournal of Venomous Animals and Toxins Including Tropical Diseases, v. 12, n. 3, p. 435-455, 2006.
dc.identifier.doi10.1590/S1678-91992006000300008
dc.identifier.file2-s2.0-33749169990.pdf
dc.identifier.issn1678-9199
dc.identifier.lattes8459981107789709
dc.identifier.lattes2179450022699059
dc.identifier.lattes6486557387397806
dc.identifier.scieloS1678-91992006000300008
dc.identifier.scopus2-s2.0-33749169990
dc.identifier.urihttp://hdl.handle.net/11449/69162
dc.identifier.wosWOS:000246281600008
dc.language.isoeng
dc.relation.ispartofJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.relation.ispartofjcr1.782
dc.relation.ispartofsjr0,573
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAnti-rabies prophylaxis
dc.subjectCytokines
dc.subjectImmunoglobulins
dc.subjectRabies
dc.subjectAnimalia
dc.subjectEquidae
dc.subjectRabies virus
dc.titleAntibody and cytokine serum levels in patients subjected to anti-rabies prophylaxis with serum-vaccinationen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/jvatitd/iaboutj.htm
unesp.advisor.lattes6486557387397806
unesp.author.lattes8459981107789709
unesp.author.lattes2179450022699059
unesp.author.lattes6840524602748457[2]
unesp.author.orcid0000-0002-9855-5594[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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