Water deprivation-induced sodium appetite

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dc.contributor.authorDe Luca, Laurival A. [UNESP]
dc.contributor.authorPereira-Derderian, Daniela T. B. [UNESP]
dc.contributor.authorVendramini, Regina C. [UNESP]
dc.contributor.authorDavid, Richard B. [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:46:08Z
dc.date.available2014-05-20T13:46:08Z
dc.date.issued2010-07-14
dc.description.abstractA water deprived animal that ingests only water efficiently corrects its intracellular dehydration, but remains hypovolemic, in negative sodium balance, and with high plasma renin activity and angiotensin II. Therefore, it is not surprising that it also ingests sodium. However, separation between thirst and sodium appetite is necessary to use water deprivation as a method to understand the mechanisms subserving sodium appetite. For this purpose, we may use the water deprivation-partial repletion protocol, or WD-PR. This protocol allows performing a sodium appetite test after the rat has quenched its thirst; thus, the sodium intake during this test cannot be confounded with a response to thirst. This is confirmed by hedonic shift and selective ingestion of sodium solutions in the sodium appetite test that follows a WD-PR. The separation between thirst and sodium appetite induced by water deprivation permits the identification of brain states associated with sodium intake in the appetite test. One of these states relates to the activation of angiotensin II All receptors. Other states relate to cell activity in key areas, e.g. subfornical organ and central amygdala, as revealed by immediate early gene c-Fos immunoreactivity or focal lesions. Angiotensin II apparently sensitizes the brain of the water deprived rat to produce an enhanced sodium intake, as that expressed by spontaneously hypertensive and by young normotensive rat. The enhancement in sodium intake produced by history of water deprivation is perhaps a clue to understand the putative salt addiction in humans.The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009. (C) 2010 Published by Elsevier B.V.en
dc.description.affiliationSão Paulo State Univ UNESP, Sch Dent, Dept Physiol & Pathol, FOAr, BR-14801903 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, FCFAr, BR-14801903 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Sch Dent, Dept Physiol & Pathol, FOAr, BR-14801903 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, FCFAr, BR-14801903 São Paulo, Brazil
dc.format.extent535-544
dc.identifierhttp://dx.doi.org/10.1016/j.physbeh.2010.02.028
dc.identifier.citationPhysiology & Behavior. Oxford: Pergamon-Elsevier B.V. Ltd, v. 100, n. 5, p. 535-544, 2010.
dc.identifier.doi10.1016/j.physbeh.2010.02.028
dc.identifier.issn0031-9384
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/16302
dc.identifier.wosWOS:000279988100016
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofPhysiology & Behavior
dc.relation.ispartofjcr2.517
dc.relation.ispartofsjr1,088
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectSodium intakeen
dc.subjectThirsten
dc.subjectMotivationen
dc.subjectDehydrationen
dc.subjectSensitizationen
dc.subjectHypertensionen
dc.titleWater deprivation-induced sodium appetiteen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0001-5677-1670[4]
unesp.author.orcid0000-0003-1167-4441[5]
unesp.author.orcid0000-0001-8270-2652[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

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