Anticaries effect of low-fluoride dentifrices with phosphates in children: A randomized, controlled trial

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Freire, I. R. [UNESP]
Pessan, J. P. [UNESP]
Amaral, J. G. [UNESP]
Martinhon, C. C.R. [UNESP]
Cunha, R. F. [UNESP]
Delbem, A. C.B. [UNESP]
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Low-fluoride dentifrices (LFD) have been recommended for young children aiming to minimize excessive fluoride intake during tooth brushing. Given the uncertainties surrounding the clinical efficacy of such formulations, alternatives to increase their anticaries effect have been investigated. Objectives This double-blind, randomized controlled trial assessed the clinical efficacy of LFDs supplemented with Calcium Glycerophosphate (CaGP) or Sodium Trimetaphosphate (TMP) on the progression of dental caries in the deciduous dentition. Methods Children (average age 48 months old) from two Brazilian cities (Araçatuba and Fernandópolis) were randomly assigned into 3 groups, according to the dentifrice to be used: 500 ppm F plus 1% TMP (500TMP, n = 206), 500 ppm F plus 0.25% CaGP (500CaGP, n = 201) and 1100 ppm F ('1100F', n = 193). Clinical exams (dmfs) were performed at baseline and 18 months after dentifrices started to be used, and the increment in the number of carious lesions (final dmfs - initial dmfs) was calculated. Data were analyzed by multivariate linear regression analysis to verify the influence of city, gender, previous caries experience and type of dentifrice on dmfs increment (p < 0.05). Results Mean caries increment observed for 500TMP (0.26) was significantly lower when compared with 1100F (0.74), while values found for 500CaGP (0.54) were not significantly different from 1100F. Caries increment was significantly higher in children from Araçatuba and in those with previous caries experience. Conclusion The results indicate that clinical efficacy of LFDs supplemented with TMP is superior to that observed for a conventional formulation (1100F), while the addition of CaGP leads to similar efficacy when compared to 1100F. Clinical Significance Children brushing with 500 ppm F toothpastes containing phosphate salts developed fewer caries lesions when compared with those using a 1100 ppm F dentifrice. The tested toothpastes can be regarded as a safe alternative to conventional formulations for children under 6 years of age, based on risk-benefit considerations.
Calcium glycerophosphate, Deciduous dentition, Dental caries, Fluoride dentifrice, Polyphosphates, Sodium trimetaphosphate
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Journal of Dentistry, v. 50, p. 37-42.