Lycopene, Mesoporous Silica Nanoparticles and Their Association: A Possible Alternative against Vulvovaginal Candidiasis?

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dc.contributor.authorCarvalho, Gabriela Corrêa [UNESP]
dc.contributor.authorMarena, Gabriel Davi [UNESP]
dc.contributor.authorLeonardi, Gabriela Ricci
dc.contributor.authorSábio, Rafael Miguel [UNESP]
dc.contributor.authorCorrêa, Ione [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.authorBauab, Tais Maria [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Ribeirão Preto (UNAERP)
dc.date.accessioned2023-07-29T15:41:51Z
dc.date.available2023-07-29T15:41:51Z
dc.date.issued2022-12-01
dc.description.abstractCommonly found colonizing the human microbiota, Candida albicans is a microorganism known for its ability to cause infections, mainly in the vulvovaginal region known as vulvovaginal candidiasis (VVC). This pathology is, in fact, one of the main C. albicans clinical manifestations, changing from a colonizer to a pathogen. The increase in VVC cases and limited antifungal therapy make C. albicans an increasingly frequent risk in women’s lives, especially in immunocompromised patients, pregnant women and the elderly. Therefore, it is necessary to develop new therapeutic options, especially those involving natural products associated with nanotechnology, such as lycopene and mesoporous silica nanoparticles. From this perspective, this study sought to assess whether lycopene, mesoporous silica nanoparticles and their combination would be an attractive product for the treatment of this serious disease through microbiological in vitro tests and acute toxicity tests in an alternative in vivo model of Galleria mellonella. Although they did not show desirable antifungal activity for VVC therapy, the present study strongly encourages the use of mesoporous silica nanoparticles impregnated with lycopene for the treatment of other human pathologies, since the products evaluated here did not show toxicity in the in vivo test performed, being therefore, a topic to be further explored.en
dc.description.affiliationSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationFaculty of Medicine University of Ribeirão Preto (UNAERP)
dc.description.affiliationMedical School São Paulo State University (UNESP)
dc.description.affiliationUnespSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespMedical School São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.3390/molecules27238558
dc.identifier.citationMolecules, v. 27, n. 23, 2022.
dc.identifier.doi10.3390/molecules27238558
dc.identifier.issn1420-3049
dc.identifier.scopus2-s2.0-85143703494
dc.identifier.urihttp://hdl.handle.net/11449/249458
dc.language.isoeng
dc.relation.ispartofMolecules
dc.sourceScopus
dc.subjectantifungal activity
dc.subjectcarotenoid
dc.subjectGalleria mellonella
dc.subjectlycopene
dc.subjectmesoporous silica nanoparticles
dc.subjectnatural products
dc.titleLycopene, Mesoporous Silica Nanoparticles and Their Association: A Possible Alternative against Vulvovaginal Candidiasis?en
dc.typeArtigo
unesp.author.orcid0000-0002-4071-5364[1]
unesp.author.orcid0000-0002-4573-5743[2]
unesp.author.orcid0000-0002-3852-2184[4]
unesp.author.orcid0000-0002-8953-9058[5]
unesp.author.orcid0000-0002-6698-0545[6]
unesp.departmentCiências Biológicas - FCFpt
unesp.departmentFármacos e Medicamentos - FCFpt

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