The effect of phosphoethanolamine intake on mortality and macrophage activity in mice with solid ehrlich tumors

Arruda, Maria Sueli Parreira de [UNESP]; Correa, Mara Adriana [UNESP]; Venturini, James [UNESP]; Félix, Maira Camila [UNESP]; De Rosis, Ana Maria Bormio [UNESP]; Galhiane, Mario Sergio [UNESP]; Chierice, Gilberto Orivaldo; Costa, Maria Renata Sales Nogueira

The effect of phosphoethanolamine intake on mortality and macrophage activity in mice with solid ehrlich tumors

Arquivos

S1516-89132011000600016.pdf (750.81 KB)

Data

2011-12-01

Autores

Arruda, Maria Sueli Parreira de

Correa, Mara Adriana

Venturini, James

Félix, Maira Camila

De Rosis, Ana Maria Bormio

Galhiane, Mario Sergio

Chierice, Gilberto Orivaldo

Costa, Maria Renata Sales Nogueira

Editor

Brazilian Archives of Biology and Technology

Tipo

Artigo

Direito de acesso

Acesso aberto

Resumo

The aim of the present study was to examine the effect of a diet rich in synthetic PEtn on the metabolism macrophages of tumor-bearing mice. The results demonstrated that PEtn increased the animals' survival time. In addition, the treated animals released smaller amounts of hydrogen peroxide (H2O2) and nitric oxide (NO) than the non-treated animals, particularly after day 14. From the results it could be concluded that H2O2 and NO were important in the modulation of neoplastic growth, and pointed to a promising role of PEtn in the control of human neoplasms.