Hypertrophied myocardium is more dependent on extracellular calcium than the normal cardiac muscle

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de Barros, Reginaldo [UNESP]
Zornoff, Leonardo A. M. [UNESP]
Ribeiro, Henrique B. [UNESP]
Okoshi, Marina P. [UNESP]
Padovani, Carlos R. [UNESP]
Aragon, Flávio F. [UNESP]
Cicogna, Antonio C. [UNESP]

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Background: The aim of this study was to analyze stable hypertrophied myocardial function and its response to inotropic maneuvers in rats submitted to renovascular hypertension for a 10-week period (RHT group, n=10). Material/Methods: Myocardial performance was studied in isolated left ventricle papillary muscles in isometric contraction under the following conditions: at postrest contraction of 30 seconds (PRC), at extracellular calcium (ECa2+) chloride concentration of 1.25 and 5.20 mM, and after beta-adrenergic stimulation with 10-6 M isoproterenol (ISOP). Results: The results were compared with normotensive Wistar controls rats (C group, n=10). In basal condition, resting tension, and contraction time (TPT) were greater, while relaxation time (RT50) tended to be longer in RHT than C group. PRC and ISOP promoted a similar change in muscle function response intensity (Δ) in both groups. ECa2+ shift did not change TPT in the C group and decreased TPT in the RHT animals; Δ was different between these groups. RT50 increased in C and decreased in RHT, both without statistical significance; however, Δ was different. Conclusions: These results suggest that hypertrophied myocardial dysfunction may be attibuted to changes in intracellular calcium cycling. © Med Sci Monit, 2010.



Calcium isoproterenol, Myocardium function, Papillary muscle, Renovascular hypertension

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Case Reports and Clinical Practice Review, v. 16, n. 8, 2010.