Polymorphisms in the AR and PSA Genes as Markers of Susceptibility and Aggressiveness in Prostate Cancer

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dc.contributor.authorKuasne, Hellen
dc.contributor.authorRodrigues, Iara Sant'Ana
dc.contributor.authorFuganti, Paulo Emilio
dc.contributor.authorLosi-Guembarovski, Roberta
dc.contributor.authorIto, Kazuhiro
dc.contributor.authorKishima, Marina O.
dc.contributor.authorde Freitas Rodrigues, Marco Aurelio
dc.contributor.authorRogatto, Silvia Regina [UNESP]
dc.contributor.authordos Santos, Rodrigo Mattos [UNESP]
dc.contributor.authorde Syllos Colus, Ilce Mara
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionLondrina Hosp Canc
dc.contributor.institutionHlth Sci Ctr
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:34:26Z
dc.date.available2014-05-20T13:34:26Z
dc.date.issued2010-11-01
dc.description.abstractThe study of genes involved in androgen pathway can contribute to a better knowledge of prostate cancer. Our aim was to examine if polymorphisms in prostate-specific antigen (PSA) and androgen receptor (AR) genes were involved in prostate cancer risk and aggressiveness. Genotypes were determined by PCR-RFLP (PSA) or using a 377 ABI DNA Sequencer (AR). PSA(G/G) genotype (OR = 1.78, 95% CI = 1.06-2.99) and AR short CAG repeats (OR = 1.89, 95% CI = 1.21-2.96) increased risk for prostate cancer and were related with tumor aggressiveness. About 38.3% of tumors showed microsatellite instability. In conclusion, polymorphisms in these genes may be indicated as potential biomarkers for prostate cancer.en
dc.description.affiliationUniversidade Estadual de Londrina (UEL), Dept Gen Biol, Ctr Biol Sci, Londrina, Parana, Brazil
dc.description.affiliationLondrina Hosp Canc, Londrina, Parana, Brazil
dc.description.affiliationUniversidade Estadual de Londrina (UEL), Dept Pathol, Hlth Sci Ctr, Londrina, Parana, Brazil
dc.description.affiliationHlth Sci Ctr, Dept Surg, Londrina, Parana, Brazil
dc.description.affiliationSão Paulo State Univ Julio de Mesquita Filho, Fac Med Botucatu, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ Julio de Mesquita Filho, Fac Med Botucatu, São Paulo, Brazil
dc.description.sponsorshipFundação Araucária de Apoio ao Desenvolvimento Científico e Tecnológico do Paraná (FAADCT/PR)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent917-924
dc.identifierhttp://dx.doi.org/10.3109/07357907.2010.483509
dc.identifier.citationCancer Investigation. Philadelphia: Taylor & Francis Inc, v. 28, n. 9, p. 917-924, 2010.
dc.identifier.doi10.3109/07357907.2010.483509
dc.identifier.issn0735-7907
dc.identifier.lattes2259986546265579
dc.identifier.urihttp://hdl.handle.net/11449/11801
dc.identifier.wosWOS:000282753800005
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofCancer Investigation
dc.relation.ispartofjcr2.053
dc.relation.ispartofsjr0,858
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAR geneen
dc.subjectGleason scoreen
dc.subjectHistopathological parametersen
dc.subjectPolymorphismsen
dc.subjectProstate Canceren
dc.subjectPSA geneen
dc.titlePolymorphisms in the AR and PSA Genes as Markers of Susceptibility and Aggressiveness in Prostate Canceren
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/page/resources/authors
dcterms.rightsHolderTaylor & Francis Inc
unesp.author.lattes2259986546265579
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentUrologia - FMBpt

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Botucatu - FMB - Faculdade de Medicina