OBTENCAO DE MESALAZINA (5-ASA) POR CARBOXILACAO DE P-AMINOFENOL

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Data

1995-01-01

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Coorientador

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Resumo

The 5-aminosalicylic acid is usually prepared: 1. by the reduction of the azodye from diazotized aniline and salicylic acid and the posterior reduction of the formed compound; 2. for carboxylation with carbon dioxide under high pressure of p-aminophenol. Both do not present high yield, but the carboxylation process of p-aminophenol can easily be used and can reduce the obtainment process of 3 steps to only 2. Another advantage of this process is the fact that the product is produced without contaminants, because only one solid reagent (p-aminophenol) and the agent of carboxylation (CO2) is used.

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Português

Como citar

Revista de Ciencias Farmaceuticas, v. 16, p. 105-110.

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