Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats

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dc.contributor.authorBrandt, Joyce Zalotti [UNESP]
dc.contributor.authorSilveira, Livia Teresa R. [UNESP]
dc.contributor.authorGrassi, Tony Fernando [UNESP]
dc.contributor.authorAnselmo-Franci, Janete A.
dc.contributor.authorFavaro, Wagner Jose
dc.contributor.authorFelisbino, Sergio Luis [UNESP]
dc.contributor.authorBarbisan, Luis Fernando [UNESP]
dc.contributor.authorScarano, Wellerson Rodrigo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-12-03T13:10:57Z
dc.date.available2014-12-03T13:10:57Z
dc.date.issued2014-01-01
dc.description.abstractBisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 mu g/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it affords chemoprotection against many types of neoplasia. Male F1 rats from different litters were euthanized on post-natal day (PND) 21 and PND180. BPA-treated groups showed a significant increase in histopathological lesions, but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C feeding increased prostate epithelial apoptosis in the BPA-treated groups and across age groups. Furthermore, I3C induced partial normalization of the prostate histoarchitecture. The results pointed to a protective effect of maternal I3C feeding during pregnancy in the BPA-exposed male offspring, thereby indicating reduction in the harmful effects of gestational BPA imprinting on the prostate. (C) 2013 Elsevier Inc. All rights reserved.en
dc.description.affiliationSao Paulo State Univ, Inst Biosci, Dept Morphol, UNESP, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUNESP, Sch Med, Dept Pathol, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUniv Sao Paulo FORP USP, Fac Dent, BR-14040904 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Inst Biol, BR-13083862 Campinas, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Inst Biosci, Dept Morphol, UNESP, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Sch Med, Dept Pathol, BR-18618970 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 10/17262-0
dc.description.sponsorshipIdFAPESP: 11/01954-2
dc.description.sponsorshipIdFAPESP: 10/14110-4
dc.description.sponsorshipIdCNPq: 471646/2011-3
dc.format.extent56-66
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2013.11.001
dc.identifier.citationReproductive Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 43, p. 56-66, 2014.
dc.identifier.doi10.1016/j.reprotox.2013.11.001
dc.identifier.issn0890-6238
dc.identifier.lattes7263490918934874
dc.identifier.lattes3278528112652257
dc.identifier.lattes3713732996827351
dc.identifier.urihttp://hdl.handle.net/11449/112670
dc.identifier.wosWOS:000331028900008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofReproductive Toxicology
dc.relation.ispartofjcr2.580
dc.relation.ispartofsjr0,846
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBisphenol Aen
dc.subjectProstateen
dc.subjectInflammationen
dc.subjectIndole-3-carbinolen
dc.subjectChemopreventionen
dc.subjectReproductive toxicologyen
dc.titleIndole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes7263490918934874
unesp.author.lattes3278528112652257
unesp.author.lattes3713732996827351
unesp.author.orcid0000-0002-2718-1564[3]
unesp.author.orcid0000-0001-5830-8938[5]
unesp.author.orcid0000-0002-6480-1187[4]
unesp.author.orcid0000-0002-6682-2934[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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