Protective action of propolis on the rat colon carcinogenesis

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dc.contributor.authorBazo, A. P.
dc.contributor.authorRodrigues, MAM
dc.contributor.authorSforcin, José Mauricio [UNESP]
dc.contributor.authorde Camargo, JLV
dc.contributor.authorRibeiro, Lúcia Regina [UNESP]
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:36:59Z
dc.date.available2014-05-20T13:36:59Z
dc.date.issued2002-01-01
dc.description.abstractPropolis is a honeybee product with several biological and therapeutical properties. Its effect on the process of colon carcinogenesis and DNA damage were evaluated in the male Wistar rats using the aberrant crypt foci (ACF) assay and the comet assay, respectively. For both tests, animals were treated with the colon carcinogen 1,2 dimethylhydrazine (DMH, 40 mg/kg, s.c.) for 2 weeks (two injections/week) in order to induce both DNA damage and ACF. The animals were divided into groups that received propolis (ethanolic extract) at three different doses (10, 30, and 90 mg/kg b.w., by gavage), either simultaneously or after DMH treatment. For the comet assay, peripheral blood samples were collected 4 h after the last DMH treatment. All animals were sacrificed at the 5th week for evaluation of ACF. The results show that only the intermediate dose (30 mg/kg) of propolis, administered after DMH initiation, is significantly associated to a smaller number of aberrant crypts in the distal colon. No effect on DNA damage in peripheral blood cells, however, was verified by the comet assay. These data suggest that propolis has a protective influence on the process of colon carcinogenesis, suppressing the development of preneoplastic lesions, and probably exerts no protection against the initiation of carcinogenesis.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Med, Dept Patol, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Inst Biociencias, Dept Microbiol & Imunol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Fac Med, Dept Patol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Inst Biociencias, Dept Microbiol & Imunol, Botucatu, SP, Brazil
dc.format.extent183-194
dc.identifierhttp://dx.doi.org/10.1002/tcm.10011
dc.identifier.citationTeratogenesis Carcinogenesis and Mutagenesis. New York: Wiley-liss, v. 22, n. 3, p. 183-194, 2002.
dc.identifier.doi10.1002/tcm.10011
dc.identifier.issn0270-3211
dc.identifier.lattes5051118752980903
dc.identifier.urihttp://hdl.handle.net/11449/12749
dc.identifier.wosWOS:000175234800003
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofTeratogenesis Carcinogenesis and Mutagenesis
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectpropolispt
dc.subjectanticarcinogenesispt
dc.subjectantimutagenesispt
dc.subjectaberrant crypt foci assaypt
dc.subjectcomet assaypt
dc.titleProtective action of propolis on the rat colon carcinogenesisen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.lattes5051118752980903
unesp.author.orcid0000-0001-9323-3134[6]
unesp.author.orcid0000-0003-3833-4172[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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