Extensive impact of saturated fatty acids on metabolic and cardiovascular profile in rats with diet-induced obesity: A canonical analysis

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dc.contributor.authorOliveira Junior, Silvio A. [UNESP]
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.authorRodrigues, Sergio A. [UNESP]
dc.contributor.authorSilva, Nilza R. [UNESP]
dc.contributor.authorMartinez, Paula F. [UNESP]
dc.contributor.authorCampos, Dijon HS [UNESP]
dc.contributor.authorOkoshi, Marina Politi [UNESP]
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.contributor.authorDal-Pai, Maeli [UNESP]
dc.contributor.authorCicogna, Antonio Carlos [UNESP]
dc.contributor.institutionFederal University of Mato Grosso do Sul
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:28:55Z
dc.date.available2014-05-27T11:28:55Z
dc.date.issued2013-04-15
dc.description.abstractBackground: Although hypercaloric interventions are associated with nutritional, endocrine, metabolic, and cardiovascular disorders in obesity experiments, a rational distinction between the effects of excess adiposity and the individual roles of dietary macronutrients in relation to these disturbances has not previously been studied. This investigation analyzed the correlation between ingested macronutrients (including sucrose and saturated and unsaturated fatty acids) plus body adiposity and metabolic, hormonal, and cardiovascular effects in rats with diet-induced obesity. Methods: Normotensive Wistar-Kyoto rats were submitted to Control (CD; 3.2 Kcal/g) and Hypercaloric (HD; 4.6 Kcal/g) diets for 20 weeks followed by nutritional evaluation involving body weight and adiposity measurement. Metabolic and hormonal parameters included glycemia, insulin, insulin resistance, and leptin. Cardiovascular analysis included systolic blood pressure profile, echocardiography, morphometric study of myocardial morphology, and myosin heavy chain (MHC) protein expression. Canonical correlation analysis was used to evaluate the relationships between dietary macronutrients plus adiposity and metabolic, hormonal, and cardiovascular parameters. Results: Although final group body weights did not differ, HD presented higher adiposity than CD. Diet induced hyperglycemia while insulin and leptin levels remained unchanged. In a cardiovascular context, systolic blood pressure increased with time only in HD. Additionally, in vivo echocardiography revealed cardiac hypertrophy and improved systolic performance in HD compared to CD; and while cardiomyocyte size was unchanged by diet, nuclear volume and collagen interstitial fraction both increased in HD. Also HD exhibited higher relative β-MHC content and β/α-MHC ratio than their Control counterparts. Importantly, body adiposity was weakly associated with cardiovascular effects, as saturated fatty acid intake was directly associated with most cardiac remodeling measurements while unsaturated lipid consumption was inversely correlated with these effects. Conclusion: Hypercaloric diet was associated with glycemic metabolism and systolic blood pressure disorders and cardiac remodeling. These effects directly and inversely correlated with saturated and unsaturated lipid consumption, respectively. © 2013 Oliveira Junior et al.; licensee BioMed Central Ltd.en
dc.description.affiliationSchool of Physical Therapy Federal University of Mato Grosso do Sul, Campo Grande, MS
dc.description.affiliationBotucatu Medical School São Paulo State University, Botucatu, SP
dc.description.affiliationBotucatu Biosciences Institute São Paulo State University, Botucatu, SP
dc.description.affiliationUnespBotucatu Medical School São Paulo State University, Botucatu, SP
dc.description.affiliationUnespBotucatu Biosciences Institute São Paulo State University, Botucatu, SP
dc.identifierhttp://dx.doi.org/10.1186/1475-2840-12-65
dc.identifier.citationCardiovascular Diabetology, v. 12, n. 1, 2013.
dc.identifier.doi10.1186/1475-2840-12-65
dc.identifier.file2-s2.0-84878907471.pdf
dc.identifier.issn1475-2840
dc.identifier.lattes9418970103564137
dc.identifier.lattes8727897080522289
dc.identifier.lattes4463138671998432
dc.identifier.lattes1590971576309420
dc.identifier.scopus2-s2.0-84878907471
dc.identifier.urihttp://hdl.handle.net/11449/75117
dc.identifier.wosWOS:000320130800001
dc.language.isoeng
dc.relation.ispartofCardiovascular Diabetology
dc.relation.ispartofjcr5.235
dc.relation.ispartofsjr2,157
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCardiac remodeling
dc.subjectHypercaloric diet
dc.subjectLipids
dc.subjectglucose
dc.subjectinsulin
dc.subjectleptin
dc.subjectmyosin heavy chain
dc.subjectsaturated fatty acid
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectbody weight
dc.subjectcardiovascular system
dc.subjectcontrolled study
dc.subjectechocardiography
dc.subjectglucose blood level
dc.subjectinsulin resistance
dc.subjectlipid diet
dc.subjectmacronutrient
dc.subjectmale
dc.subjectmetabolism
dc.subjectmorphometrics
dc.subjectnonhuman
dc.subjectobesity
dc.subjectprotein expression
dc.subjectrat
dc.subjectsystolic blood pressure
dc.titleExtensive impact of saturated fatty acids on metabolic and cardiovascular profile in rats with diet-induced obesity: A canonical analysisen
dc.typeArtigo
dcterms.licensehttp://www.biomedcentral.com/about/license
unesp.author.lattes9418970103564137[10]
unesp.author.lattes8727897080522289[2]
unesp.author.lattes4463138671998432
unesp.author.lattes1590971576309420
unesp.author.orcid0000-0002-2091-2141[3]
unesp.author.orcid0000-0002-8895-9456[1]
unesp.author.orcid0000-0002-7719-9682[2]
unesp.author.orcid0000-0001-8980-8839[8]
unesp.author.orcid0000-0002-4402-6523[10]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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