Chemopreventive property of dietary ginger in rat urinary bladder chemical carcinogenesis

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dc.contributor.authorIhlaseh, Shadia Muhammad
dc.contributor.authorOliveira, Maria Luiza Cotrim Sartor de [UNESP]
dc.contributor.authorTeran, Elizabeth
dc.contributor.authorCamargo, João Lauro Viana de [UNESP]
dc.contributor.authorBarbisan, Luis Fernando [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:36:59Z
dc.date.available2014-05-20T13:36:59Z
dc.date.issued2006-11-01
dc.description.abstractThe modifying potential of ginger on the development of preneoplasia and tumors in the male Wistar rat urinary bladder was investigated in a 36-week-long initiation-promotion assay for chemical carcinogenesis. Groups G1 to G3 were given 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in drinking water for 5 weeks and a 3% uracil meal for the subsequent 3 weeks. Groups G4 and G5 were treated with 3% uracil only for the same period. After these steps, groups G2, and G3 and G4 were fed for 26 weeks a ginger extract mixed at 0.5 and 1.0% in a basal diet, respectively. Thirty six weeks after the beginning of the experiment all rats were killed. The multiplicity of urothelial lesions (hyperplasia and neoplasia) was significantly lower (P = 0.013) in group G3 than in groups G1 and G2. The results suggest that 1.0% ginger meal exerts a protective effect on the post-initiation stage of rat chemically-induced urothelial carcinogenesis.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Inst Biosci, Dept Morphol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Sch Med, Dept Pathol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationGrp CentroFlora, BR-18603970 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Inst Biosci, Dept Morphol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Sch Med, Dept Pathol, BR-18618000 Botucatu, SP, Brazil
dc.format.extent591-596
dc.identifierhttp://dx.doi.org/10.1007/s00345-006-0108-9
dc.identifier.citationWorld Journal of Urology. New York: Springer, v. 24, n. 5, p. 591-596, 2006.
dc.identifier.doi10.1007/s00345-006-0108-9
dc.identifier.issn0724-4983
dc.identifier.lattes3278528112652257
dc.identifier.urihttp://hdl.handle.net/11449/12757
dc.identifier.wosWOS:000242154500014
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofWorld Journal of Urology
dc.relation.ispartofjcr2.981
dc.relation.ispartofsjr1,272
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectgingerpt
dc.subjectchemopreventionpt
dc.subjectrat urothelial carcinogenesispt
dc.titleChemopreventive property of dietary ginger in rat urinary bladder chemical carcinogenesisen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes3278528112652257
unesp.author.orcid0000-0003-3833-4172[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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