Genetic and modifying factors that determine the risk of brain tumors

Página do item simplificado
dc.contributor.authorde Cresci Braga Montelli, Terezinha [UNESP]
dc.contributor.authorPeraçoli, Maria Terezinha Serrão [UNESP]
dc.contributor.authorRogatto, Silvia Regina [UNESP]
dc.contributor.authorKaneno, Ramon [UNESP]
dc.contributor.authordo Prado, Cíntia Helena Braga Montelli [UNESP]
dc.contributor.authorde Medeiros Cardassi Rocha, Patrícia [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionAC Camargo Hospital
dc.date.accessioned2014-05-27T11:25:30Z
dc.date.available2014-05-27T11:25:30Z
dc.date.issued2011-03-29
dc.description.abstractSome modifying factors may determine the risk of brain tumors. Until now, it could not be attempted to identify people at risk and also to improve significantly disease progression. Current therapy consists of surgical resection, followed by radiation therapy and chemotherapy. Despite of these treatments, the prognosis for patients is poor. In this review, we highlight general aspects concerning genetic alterations in brain tumors, namely astrocytomas, glioblastomas, oligodendrogliomas, medulloblastomas and ependymomas. The influence of these genetic alterations in patients' prognosis is discussed. Mutagen sensivity is associated with cancer risk. The convincing studies that linked DNA damages and DNA repair alterations with brain tumors are also described. Another important modifying factor is immunity. General immune response against cancer, tumor microenvironment and immune response, mechanisms of tumor escape, CNS tumor immunology, immune defects that impair anti-tumor systemic immunity in brain tumor patients and local immunosuppressive factors within CNS are also reviewed. New hope to treatment perspectives, as dendritic-cell-based vaccines is summarized too. Concluding, it seems well established that there is association between brain tumor risk and mutagen sensivity, which is highly heritable. Primary brain tumors cause depression in systemic host immunity; local immunosuppressive factors and immunological characteristics of tumor cells may explain the poor prognosis and DNA damages responses can alert immune system. However, it is necessary to clarify if individuals with both constitutional defects in immune functions and genetic instability have higher risk of developing brain tumors. Cytogenetic prospective studies and gene copy number variations analysis also must be performed in peripheral lymphocytes from brain tumor patients. © 2011 Bentham Science Publishers Ltd.en
dc.description.affiliationBotucatu Medical School São Paulo State University, Rua General Telles, 267, 18600-030 Botucatu - SP
dc.description.affiliationInstitute of Biosciences São Paulo State University, Botucatu, SP
dc.description.affiliationAC Camargo Hospital, São Paulo, SP
dc.description.affiliationUnespBotucatu Medical School São Paulo State University, Rua General Telles, 267, 18600-030 Botucatu - SP
dc.description.affiliationUnespInstitute of Biosciences São Paulo State University, Botucatu, SP
dc.format.extent8-30
dc.identifierhttp://dx.doi.org/10.2174/187152411794961095
dc.identifier.citationCentral Nervous System Agents in Medicinal Chemistry, v. 11, n. 1, p. 8-30, 2011.
dc.identifier.doi10.2174/187152411794961095
dc.identifier.issn1871-5249
dc.identifier.lattes2259986546265579
dc.identifier.lattes8845835550637809
dc.identifier.lattes6486557387397806
dc.identifier.orcid0000-0002-4292-3298
dc.identifier.scopus2-s2.0-79953002632
dc.identifier.urihttp://hdl.handle.net/11449/72344
dc.language.isoeng
dc.relation.ispartofCentral Nervous System Agents in Medicinal Chemistry
dc.relation.ispartofsjr0,423
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAdaptive immunity
dc.subjectBrain tumors
dc.subjectCellular immunity
dc.subjectDendritic cell-based vaccines
dc.subjectDNA copy number variations
dc.subjectDNA repair
dc.subjectInnate immunity
dc.subjectantineoplastic agent
dc.subjectdendritic cell vaccine
dc.subjectastrocytoma
dc.subjectblood brain barrier
dc.subjectbrachytherapy
dc.subjectbrain infection
dc.subjectbrain tumor
dc.subjectcancer adjuvant therapy
dc.subjectcancer immunology
dc.subjectcancer risk
dc.subjectcarcinogenesis
dc.subjectdendritic cell
dc.subjectDNA damage
dc.subjectependymoma
dc.subjectgene dosage
dc.subjectgene mutation
dc.subjectgenetic analysis
dc.subjectgenetic association
dc.subjectglioblastoma
dc.subjectheredity
dc.subjecthuman
dc.subjectimmune deficiency
dc.subjectimmune response
dc.subjectlymphocyte
dc.subjectmedulloblastoma
dc.subjectnonhuman
dc.subjectoligodendroglioma
dc.subjectprognosis
dc.subjectreview
dc.subjectT lymphocyte
dc.subjecttumor escape
dc.subjecttumor microenvironment
dc.subjectBlood-Brain Barrier
dc.subjectBrain Neoplasms
dc.subjectChromosome Aberrations
dc.subjectDendritic Cells
dc.subjectDisease Progression
dc.subjectDNA Copy Number Variations
dc.subjectHumans
dc.subjectImmune System
dc.subjectImmunotherapy
dc.subjectNeoplastic Stem Cells
dc.subjectRisk Factors
dc.subjectTumor Escape
dc.subjectTumor Microenvironment
dc.titleGenetic and modifying factors that determine the risk of brain tumorsen
dc.typeResenha
dcterms.licensehttp://eurekaselect.com/209
unesp.advisor.lattes6486557387397806
unesp.author.lattes2259986546265579
unesp.author.lattes8845835550637809[4]
unesp.author.orcid0000-0002-4292-3298[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

Arquivos

Coleções

Artigos - Microbiologia e Imunologia - IBB
Artigos - Urologia - FMB