Anxiolytic-like effects of erythrinian alkaloids from erythrina suberosa

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Serrano, Maria Amélia Rodrigues [UNESP]
De Luca Batista, Andrea Nastri [UNESP]
Da Silva Bolzani, Vanderlan [UNESP]
De Ávila Santos, Luciana [UNESP]
De Campos Nogueira, Paulo José [UNESP]
Nunes-De-Souza, Ricardo Luiz [UNESP]
Latif, Abdul
Arfan, Mohammad

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Two alkaloids, erysodine (1) and erysothrine (2) were isolated from the flowers of a Pakistani medicinal plant, Erythrina suberosa. These compounds were investigated for anxiolytic properties, and the results showed significant effect, in an acute oral treatment with 1-2, which were suspended in saline (NaCl 0.9%) plus DMSO 1%, and evaluated in 122 Swiss male mice exposed to two tests of anxiety - the elevated plus-maze (EPM) and the light/dark transition model (LDTM).



Anxyolitic activity, E. suberosa, Erythrinian alkaloids

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Quimica Nova, v. 34, n. 5, p. 808-811, 2011.