HLA-G liver expression and HLA-G extended haplotypes are associated with chronic hepatitis C in HIV-negative and HIV-coinfected patients
dc.contributor.author | Bertol, Bruna Cristina | |
dc.contributor.author | Dias, Fabricio Cesar | |
dc.contributor.author | Debortoli, Guilherme | |
dc.contributor.author | Souto, Bruno Mendes | |
dc.contributor.author | Mendonca, Priscila Baptista | |
dc.contributor.author | Araujo, Roberta Chaves | |
dc.contributor.author | Santana, Rodrigo Carvalho | |
dc.contributor.author | Zambelli Ramalho, Leandra Naira | |
dc.contributor.author | Castelli, Erick Cruz [UNESP] | |
dc.contributor.author | Candolo Martinelli, Ana de Lourdes | |
dc.contributor.author | Mendes-Junior, Celso Teixeira | |
dc.contributor.author | Carosella, Edgardo Delfino | |
dc.contributor.author | Donadi, Eduardo Antonio | |
dc.contributor.author | Moreau, Philippe | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Hop St Louis | |
dc.contributor.institution | Univ Paris Diderot | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2020-12-10T20:05:28Z | |
dc.date.available | 2020-12-10T20:05:28Z | |
dc.date.issued | 2020-08-01 | |
dc.description.abstract | Chronic hepatitis C virus (HCV) infection induces liver damage and the HCV/Human Immunodeficiency Virus (HIV)-coinfection may further contribute to its progression. The HLA-G molecule inhibits innate and adaptive immunity and may be deleterious for chronically virus-infected cells. Thus we studied 204 HCV-mono-infected patients, 142 HCV/HIV-coinfected patients, 104 HIV-mono-infected patients and 163 healthy subjects. HLA-G liver expression was similarly induced in HCV and HCV/HIV specimens, increasing with advanced fibrosis and necroinflammatory activity, and with increased levels of liver function-related enzymes. Plasma soluble HLA-G (sHLA-G) levels were higher in HCV/HIV patients compared to HCV, HIV and to healthy individuals. sHLA-G continued to be higher in coinfected patients even after stratification of samples according to degree of liver fibrosis and necroinflammatory activity when compared to mono-infected patients. Some HLA-G gene haplo-types differentiated patient groups and presented few associations with liver and plasma HLA-G expression. HLA-G thus may help to distinguish patient groups. | en |
dc.description.affiliation | Univ Sao Paulo, Ribeirao Preto Med Sch, Postgrad Program Basic & Appl Immunol, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto, Brazil | |
dc.description.affiliation | Univ Sao Paulo, Ribeirao Preto Med Sch, Div Clin Immunol, Dept Med, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto, Brazil | |
dc.description.affiliation | Hop St Louis, Commissariat Energie Atom & Energies Alternat, Direct Rech Fondamentale, Inst Biol Francois Jacob,Serv Rech Hematoimmunol, 1 Ave Claude Vellefaux, F-75475 Paris, France | |
dc.description.affiliation | Univ Paris Diderot, Inst Rech St Louis, HIPI, UMR 976, 1 Ave Claude Vellefaux, F-75475 Paris, France | |
dc.description.affiliation | Univ Sao Paulo, Ribeirao Preto Med Sch, Postgrad Program Genet, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto, Brazil | |
dc.description.affiliation | Univ Sao Paulo, Ribeirao Preto Med Sch, Div Gastroenterol, Dept Med, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto, Brazil | |
dc.description.affiliation | Univ Sao Paulo, Ribeirao Preto Med Sch, Div Infect & Trop Dis, Dept Med, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto, Brazil | |
dc.description.affiliation | Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pathol, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto, Brazil | |
dc.description.affiliation | Sao Paulo State Univ, Dept Pathol, Sch Med, Av Dr Mario Rubens Guimaraes Montenegro, BR-18618687 Botucatu, SP, Brazil | |
dc.description.affiliation | Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto, Brazil | |
dc.description.affiliationUnesp | Sao Paulo State Univ, Dept Pathol, Sch Med, Av Dr Mario Rubens Guimaraes Montenegro, BR-18618687 Botucatu, SP, Brazil | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorship | Science Without Borders | |
dc.description.sponsorship | Universidade de Sao Paulo-Comite Francais d'Evaluation de la Cooperation Universitaire et Scientifique avec le Bresil (USP/COFECUB) | |
dc.description.sponsorship | Agence Nationale de Recherches sur le Sida et les hepatites virales (ANRS) | |
dc.description.sponsorship | Universite Sorbonne Paris Cite (USPC) | |
dc.description.sponsorship | Universidade de Sao Paulo-Universite Sorbonne Paris Cite | |
dc.description.sponsorship | Commissariat a l'Energie Atomique et aux Energies Alternatives (CEA) | |
dc.description.sponsorshipId | CAPES: 653/09 | |
dc.description.sponsorshipId | Science Without Borders: 236754/2012-2 | |
dc.description.sponsorshipId | CNPq: 466036/2013-5 | |
dc.description.sponsorshipId | CNPq: 304931/2014-4 | |
dc.description.sponsorshipId | Universidade de Sao Paulo-Comite Francais d'Evaluation de la Cooperation Universitaire et Scientifique avec le Bresil (USP/COFECUB): 2017.1.1337.1.5 | |
dc.description.sponsorshipId | Agence Nationale de Recherches sur le Sida et les hepatites virales (ANRS): 12296/2013 | |
dc.description.sponsorshipId | : 406594/2013-9 | |
dc.description.sponsorshipId | : 401641/2013-9 | |
dc.format.extent | 12 | |
dc.identifier | http://dx.doi.org/10.1016/j.clim.2020.108482 | |
dc.identifier.citation | Clinical Immunology. San Diego: Academic Press Inc Elsevier Science, v. 217, 12 p., 2020. | |
dc.identifier.doi | 10.1016/j.clim.2020.108482 | |
dc.identifier.issn | 1521-6616 | |
dc.identifier.uri | http://hdl.handle.net/11449/197077 | |
dc.identifier.wos | WOS:000548738300009 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Clinical Immunology | |
dc.source | Web of Science | |
dc.subject | Human leukocyte antigen-G | |
dc.subject | Soluble HLA-G | |
dc.subject | HLA-G polymorphisms | |
dc.subject | HCV/HIV-coinfection | |
dc.subject | Antiviral immunity | |
dc.title | HLA-G liver expression and HLA-G extended haplotypes are associated with chronic hepatitis C in HIV-negative and HIV-coinfected patients | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
unesp.author.orcid | 0000-0003-4320-5850[3] | |
unesp.author.orcid | 0000-0002-2868-7401[14] |