HLA-G liver expression and HLA-G extended haplotypes are associated with chronic hepatitis C in HIV-negative and HIV-coinfected patients

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dc.contributor.authorBertol, Bruna Cristina
dc.contributor.authorDias, Fabricio Cesar
dc.contributor.authorDebortoli, Guilherme
dc.contributor.authorSouto, Bruno Mendes
dc.contributor.authorMendonca, Priscila Baptista
dc.contributor.authorAraujo, Roberta Chaves
dc.contributor.authorSantana, Rodrigo Carvalho
dc.contributor.authorZambelli Ramalho, Leandra Naira
dc.contributor.authorCastelli, Erick Cruz [UNESP]
dc.contributor.authorCandolo Martinelli, Ana de Lourdes
dc.contributor.authorMendes-Junior, Celso Teixeira
dc.contributor.authorCarosella, Edgardo Delfino
dc.contributor.authorDonadi, Eduardo Antonio
dc.contributor.authorMoreau, Philippe
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionHop St Louis
dc.contributor.institutionUniv Paris Diderot
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-10T20:05:28Z
dc.date.available2020-12-10T20:05:28Z
dc.date.issued2020-08-01
dc.description.abstractChronic hepatitis C virus (HCV) infection induces liver damage and the HCV/Human Immunodeficiency Virus (HIV)-coinfection may further contribute to its progression. The HLA-G molecule inhibits innate and adaptive immunity and may be deleterious for chronically virus-infected cells. Thus we studied 204 HCV-mono-infected patients, 142 HCV/HIV-coinfected patients, 104 HIV-mono-infected patients and 163 healthy subjects. HLA-G liver expression was similarly induced in HCV and HCV/HIV specimens, increasing with advanced fibrosis and necroinflammatory activity, and with increased levels of liver function-related enzymes. Plasma soluble HLA-G (sHLA-G) levels were higher in HCV/HIV patients compared to HCV, HIV and to healthy individuals. sHLA-G continued to be higher in coinfected patients even after stratification of samples according to degree of liver fibrosis and necroinflammatory activity when compared to mono-infected patients. Some HLA-G gene haplo-types differentiated patient groups and presented few associations with liver and plasma HLA-G expression. HLA-G thus may help to distinguish patient groups.en
dc.description.affiliationUniv Sao Paulo, Ribeirao Preto Med Sch, Postgrad Program Basic & Appl Immunol, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto, Brazil
dc.description.affiliationUniv Sao Paulo, Ribeirao Preto Med Sch, Div Clin Immunol, Dept Med, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto, Brazil
dc.description.affiliationHop St Louis, Commissariat Energie Atom & Energies Alternat, Direct Rech Fondamentale, Inst Biol Francois Jacob,Serv Rech Hematoimmunol, 1 Ave Claude Vellefaux, F-75475 Paris, France
dc.description.affiliationUniv Paris Diderot, Inst Rech St Louis, HIPI, UMR 976, 1 Ave Claude Vellefaux, F-75475 Paris, France
dc.description.affiliationUniv Sao Paulo, Ribeirao Preto Med Sch, Postgrad Program Genet, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto, Brazil
dc.description.affiliationUniv Sao Paulo, Ribeirao Preto Med Sch, Div Gastroenterol, Dept Med, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto, Brazil
dc.description.affiliationUniv Sao Paulo, Ribeirao Preto Med Sch, Div Infect & Trop Dis, Dept Med, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto, Brazil
dc.description.affiliationUniv Sao Paulo, Ribeirao Preto Med Sch, Dept Pathol, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto, Brazil
dc.description.affiliationSao Paulo State Univ, Dept Pathol, Sch Med, Av Dr Mario Rubens Guimaraes Montenegro, BR-18618687 Botucatu, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Dept Pathol, Sch Med, Av Dr Mario Rubens Guimaraes Montenegro, BR-18618687 Botucatu, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipScience Without Borders
dc.description.sponsorshipUniversidade de Sao Paulo-Comite Francais d'Evaluation de la Cooperation Universitaire et Scientifique avec le Bresil (USP/COFECUB)
dc.description.sponsorshipAgence Nationale de Recherches sur le Sida et les hepatites virales (ANRS)
dc.description.sponsorshipUniversite Sorbonne Paris Cite (USPC)
dc.description.sponsorshipUniversidade de Sao Paulo-Universite Sorbonne Paris Cite
dc.description.sponsorshipCommissariat a l'Energie Atomique et aux Energies Alternatives (CEA)
dc.description.sponsorshipIdCAPES: 653/09
dc.description.sponsorshipIdScience Without Borders: 236754/2012-2
dc.description.sponsorshipIdCNPq: 466036/2013-5
dc.description.sponsorshipIdCNPq: 304931/2014-4
dc.description.sponsorshipIdUniversidade de Sao Paulo-Comite Francais d'Evaluation de la Cooperation Universitaire et Scientifique avec le Bresil (USP/COFECUB): 2017.1.1337.1.5
dc.description.sponsorshipIdAgence Nationale de Recherches sur le Sida et les hepatites virales (ANRS): 12296/2013
dc.description.sponsorshipId: 406594/2013-9
dc.description.sponsorshipId: 401641/2013-9
dc.format.extent12
dc.identifierhttp://dx.doi.org/10.1016/j.clim.2020.108482
dc.identifier.citationClinical Immunology. San Diego: Academic Press Inc Elsevier Science, v. 217, 12 p., 2020.
dc.identifier.doi10.1016/j.clim.2020.108482
dc.identifier.issn1521-6616
dc.identifier.urihttp://hdl.handle.net/11449/197077
dc.identifier.wosWOS:000548738300009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofClinical Immunology
dc.sourceWeb of Science
dc.subjectHuman leukocyte antigen-G
dc.subjectSoluble HLA-G
dc.subjectHLA-G polymorphisms
dc.subjectHCV/HIV-coinfection
dc.subjectAntiviral immunity
dc.titleHLA-G liver expression and HLA-G extended haplotypes are associated with chronic hepatitis C in HIV-negative and HIV-coinfected patientsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0003-4320-5850[3]
unesp.author.orcid0000-0002-2868-7401[14]

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