Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol

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Saad, William A. [UNESP]
Luiz, A. C. [UNESP]
Camargo, L. A A [UNESP]
Silveira, J. E N [UNESP]
Fóglia, S. [UNESP]
Menani, José Vanderlei [UNESP]

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We investigated the effects of losartan, an AT 1-receptor blocker, and ramipril, a converting enzyme inhibitor, on the pressor response induced by angiotensin II (ANG II) and carbachol (a cholinergic receptor agonist). Male Holtzman rats (250-300 g) with a stainless steel cannula implanted into the lateral ventricle (LV) were used. The injection of losartan (50 nmol/l μl) into the LV blocked the pressor response induced by ANG II (12 ng/l μl) and carbachol (2 nmol/l μl). After injection of ANG II and carbachol into the LV, mean arterial pressure (MAP) increased to 31 ± 1 and 28 ± 2 mmHg, respectively. Previous injection of losartan abolished the increase in MAP induced by ANG II and carbachol into the LV (2 ± 1 and 5 ± 2 mmHg, respectively). The injection of ramipril (12 ng/l μl) prior to carbachol blocked the pressor effect of carbachol to 7 ± 3 mmHg. These results suggest an interaction between central cholinergic pathways and the angiotensinergic system in the regulation of arterial blood pressure.



carbachol, central angiotensin, pressor response, angiotensin, losartan, losartan potassium, ramipril, animal experiment, cholinergic system, conference paper, controlled study, intracerebroventricular drug administration, male, nonhuman, rat, renin angiotensin aldosterone system, Angiotensin-Converting Enzyme Inhibitors, Animals, Blood Pressure, Carbachol, Cerebral Ventricles, Cholinergic Agonists, Losartan, Male, Pressoreceptors, Ramipril, Rats, Rats, Sprague-Dawley, Receptors, Angiotensin, Renin-Angiotensin System, Animalia

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Brazilian Journal of Medical and Biological Research, v. 30, n. 4, p. 493-496, 1997.