Curcumin reduces inflammation in rat apical periodontitis

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dc.contributor.authorJusto, Mariana Pagliusi [UNESP]
dc.contributor.authorCardoso, Carolina de Barros Morais [UNESP]
dc.contributor.authorCantiga-Silva, Cristiane [UNESP]
dc.contributor.authorOliveira, Pedro Henrique Chaves de [UNESP]
dc.contributor.authorSivieri-Araujo, Gustavo [UNESP]
dc.contributor.authorAzuma, Mariane Maffei [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorCintra, Luciano Tavares Angelo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-11-30T13:46:24Z
dc.date.available2022-11-30T13:46:24Z
dc.date.issued2022-09-05
dc.description.abstractAim The aim of the study was to evaluate the effect of systemic curcumin administration on the severity of apical periodontitis (AP). Methodology Forty male Wistar rats weighing 250-280 g each, age 2.5 months, were distributed into four groups (n = 10): control untreated rats (C), control rats treated with curcumin (CUR), rats with pulp exposure-induced apical periodontitis (AP) and rats with pulp exposure-induced apical periodontitis treated with curcumin (AP-CUR). Curcumin treatment was administered orally once daily for 15 days before pulp exposure and continued for 30 days after pulp exposure. The rats were sacrificed at 30 days, and the jaws were collected and reconstructed in a programme specific for micro-CT. The jaws were processed for analysis of the inflammatory process using haematoxylin and eosin staining and immunohistochemical assays for interleukin tumour necrosis factor alpha (TNF-alpha), interleukin (Il)-6 and Il-1 beta. Tartrate-resistant acid phosphatase (TRAP) and osteocalcin (OCN) staining were used to analyse the resorptive process on the bone surface of periapical area. Kruskal-Wallis with Dunn's test was performed for nonparametric data and anova with Tukey's test for parametric data, p < .05. Results Micro-CT revealed no statistically significant differences in bone resorption between the AP and AP-CUR groups (p > .05). The levels of inflammatory cell infiltration and immunoreactivity for the proinflammatory cytokines TNF-alpha, Il-6 and Il-1 beta were significantly higher in the periapical lesions of the AP group than in the AP-CUR group (p < .05). The number of TRAP-positive multinucleated cells was higher in the AP group than in the AP-CUR group (p < .05). In OCN-positive cells, no differences were observed between the AP and AP-CUR groups (p > .05). Conclusions Oral supplementation with curcumin had a significant effect on the AP severity in rats, suggesting an anti-inflammatory effect of curcumin on AP development.en
dc.description.affiliationSao Paulo State Univ Unesp, Sch Dent, Endodont Sect, Dept Prevent & Restorat Dent, Sao Paulo, Brazil
dc.description.affiliationSao Paulo State Univ Unesp, Sch Dent, Dept Basic Sci, Aracatuba, Brazil
dc.description.affiliationSao Paulo State Univ UNESP, Dent Assistance Ctr Disabled Persons CAOE, Sch Dent, Aracatuba, Brazil
dc.description.affiliationUnespSao Paulo State Univ Unesp, Sch Dent, Endodont Sect, Dept Prevent & Restorat Dent, Sao Paulo, Brazil
dc.description.affiliationUnespSao Paulo State Univ Unesp, Sch Dent, Dept Basic Sci, Aracatuba, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Dent Assistance Ctr Disabled Persons CAOE, Sch Dent, Aracatuba, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifco e Tecnologico
dc.description.sponsorshipIdFAPESP: 2018/18661-7
dc.description.sponsorshipIdConselho Nacional de Desenvolvimento Cientifco e Tecnologico: 315381/2021-3
dc.format.extent11
dc.identifierhttp://dx.doi.org/10.1111/iej.13819
dc.identifier.citationInternational Endodontic Journal. Hoboken: Wiley, 11 p., 2022.
dc.identifier.doi10.1111/iej.13819
dc.identifier.issn0143-2885
dc.identifier.urihttp://hdl.handle.net/11449/237842
dc.identifier.wosWOS:000850095900001
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofInternational Endodontic Journal
dc.sourceWeb of Science
dc.subjectApical periodontitis
dc.subjectCurcumin
dc.subjectCytokine
dc.subjectEndodontic infection
dc.titleCurcumin reduces inflammation in rat apical periodontitisen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.orcid0000-0002-1593-7926[4]
unesp.author.orcid0000-0002-8402-7408[5]

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Artigos - Ciências Básicas - FOA
Araçatuba - CAOE - Centro de Assistência Odontológica a Excepcionais