Expression of fibroblast growth factor 10 and cognate receptors in the developing bovine ovary

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dc.contributor.authorCastilho, A. C. S. [UNESP]
dc.contributor.authorBueno da Silva, R. [UNESP]
dc.contributor.authorPrice, C. A.
dc.contributor.authorMachado, M. F. [UNESP]
dc.contributor.authorAmorim, Renée Laufer [UNESP]
dc.contributor.authorBuratini, J. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Montreal
dc.date.accessioned2014-12-03T13:10:52Z
dc.date.available2014-12-03T13:10:52Z
dc.date.issued2014-06-01
dc.description.abstractIn the mammalian ovary, FGF10 is expressed in oocytes and theca cells and is a candidate for paracrine signaling to the developing granulosa cells. To gain insight into the participation of FGF10 in the regulation of fetal folliculogenesis, we assessed mRNA expression patterns of FGF10 and its receptors, FGFR1B and FGFR2B, in relation to fetal follicle dynamics and localized FGF10 protein in bovine fetal ovaries at different ages. Primordial, primary, secondary, and antral follicles were first observed on Days 75, 90, 150, and 210 of gestation, respectively. The levels of GDF9 and BMP15 mRNA, markers for primordial and primary follicles, respectively, increased during fetal ovary development in a consistent manner with fetal follicle dynamics. CYP17A1 mRNA abundance increased from Day 60 to Day 75 and then from Day 120 to Day 150, coinciding with the appearance of secondary follicles. FGF10 mRNA abundance increased from Day 90, and this increase was temporally associated with increases in FGFR1B mRNA abundance and in the population of primary follicles. In contrast, FGFR2B mRNA expression was highest on Day 60 and decreased thereafter. FGF10 protein was localized to oogonia and oocytes and surrounding granulosa cells at all fetal ages. The present data suggest a role for FGF10 in the control of fetal folliculogenesis in cattle. (C) 2014 Published by Elsevier Inc.en
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Farmacol, Botucatu, SP, Brazil
dc.description.affiliationUniv Montreal, Fac Med Vet, Ctr Rech Reprod Anim, St Hyacinthe, PQ J2S 7C6, Canada
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Fisiol, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Med Vet & Zootecnia, Dept Clin Vet, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Farmacol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Fisiol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med Vet & Zootecnia, Dept Clin Vet, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent1268-1274
dc.identifierhttp://dx.doi.org/10.1016/j.theriogenology.2014.02.008
dc.identifier.citationTheriogenology. New York: Elsevier Science Inc, v. 81, n. 9, p. 1268-1274, 2014.
dc.identifier.doi10.1016/j.theriogenology.2014.02.008
dc.identifier.issn0093-691X
dc.identifier.urihttp://hdl.handle.net/11449/112605
dc.identifier.wosWOS:000335710600013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofTheriogenology
dc.relation.ispartofjcr2.136
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectFGF10en
dc.subjectOvaryen
dc.subjectPreantral folliclesen
dc.subjectOogoniaen
dc.subjectBovineen
dc.titleExpression of fibroblast growth factor 10 and cognate receptors in the developing bovine ovaryen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-6727-8280[3]
unesp.author.orcid0000-0003-1666-7021[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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Artigos - Farmacologia - IBB
Artigos - Clínica Veterinária - FMVZ
Artigos - Fisiologia - IBB