Tobacco Smoke Induces Ventricular Remodeling Associated with an Increase in NADPH Oxidase Activity

Página do item simplificado
dc.contributor.authorRafacho, Bruna P. M. [UNESP]
dc.contributor.authorGaiolla, Paula Schmidt Azevedo [UNESP]
dc.contributor.authorPolegato, Bertha Furlan [UNESP]
dc.contributor.authorFernandes, Ana Angelica Henrique [UNESP]
dc.contributor.authorBertoline, Maria A.
dc.contributor.authorFernandes, Denise C.
dc.contributor.authorChiuso-Minicucci, Fernanda [UNESP]
dc.contributor.authorRoscani, Meliza Goi [UNESP]
dc.contributor.authordos Santos, Priscila P. [UNESP]
dc.contributor.authorMatsubara, Luiz Shiguero [UNESP]
dc.contributor.authorMatsubara, Beatriz Bojikian [UNESP]
dc.contributor.authorLaurindo, Francisco R. M.
dc.contributor.authorPaiva, Sergio Alberto Rupp de [UNESP]
dc.contributor.authorZornoff, Leonardo Antonio Mamede [UNESP]
dc.contributor.authorMinicucci, Marcos Ferreira [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:50:52Z
dc.date.available2014-05-20T13:50:52Z
dc.date.issued2011-01-01
dc.description.abstractBackground: Recent studies have assessed the direct effects of smoking on cardiac remodeling and function. However, the mechanisms of these alterations remain unknown. The aim of this study was to investigate de role of cardiac NADPH oxidase and antioxidant enzyme system on ventricular remodeling induced by tobacco smoke. Methods: Male Wistar rats that weighed 200-230 g were divided into a control group (C) and an experimental group that was exposed to tobacco smoke for a period of two months (ETS). After the two-month exposure period, morphological, biochemical and functional analyses were performed. Results: The myocyte cross-sectional area and left ventricle end-diastolic dimension was increased 16.2% and 33.7%, respectively, in the ETS group. The interstitial collagen volume fraction was also higher in ETS group compared to the controls. In addition to these morphological changes, the ejection fraction and fractional shortening were decreased in the ETS group. Importantly, these alterations were related to augmented heart oxidative stress, which was characterized by an increase in NADPH oxidase activity, increased levels of lipid hydroperoxide and depletion of antioxidant enzymes (e.g., catalase, superoxide dismutase and glutathione peroxidase). In addition, cardiac levels of IFN-gamma, TNF-alpha and IL-10 were not different between the groups. Conclusion: Cardiac alterations that are induced by smoking are associated with increased NADPH oxidase activity, suggesting that this pathway plays a role in the ventricular remodeling induced by exposure to tobacco smoke. Copyright (C) 2011 S. Karger AG, Baselen
dc.description.affiliationUniv Estadual Paulista, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biol Sci, Dept Chem & Biochem, Botucatu, SP, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Heart Inst InCor, Vasc Biol Lab, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biol Sci, Dept Chem & Biochem, Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent305-312
dc.identifierhttp://dx.doi.org/10.1159/000327957
dc.identifier.citationCellular Physiology and Biochemistry. Basel: Karger, v. 27, n. 3-4, p. 305-312, 2011.
dc.identifier.doi10.1159/000327957
dc.identifier.fileWOS000290594900015.pdf
dc.identifier.issn1015-8987
dc.identifier.lattes6309835137998766
dc.identifier.lattes6990977122340795
dc.identifier.lattes5016839015394547
dc.identifier.lattes1213140801402647
dc.identifier.lattes7438704034471673
dc.identifier.orcid0000-0002-5843-6232
dc.identifier.urihttp://hdl.handle.net/11449/18153
dc.identifier.wosWOS:000290594900015
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofCellular Physiology and Biochemistry
dc.relation.ispartofjcr5.500
dc.relation.ispartofsjr1,561
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectOxidative stressen
dc.subjectTobacco smoke exposureen
dc.subjectCardiac remodelingen
dc.titleTobacco Smoke Induces Ventricular Remodeling Associated with an Increase in NADPH Oxidase Activityen
dc.typeArtigo
dcterms.licensehttp://www.karger.com/Services/OpenAccessLicense
dcterms.rightsHolderKarger
unesp.author.lattes6309835137998766
unesp.author.lattes6990977122340795
unesp.author.lattes1213140801402647[2]
unesp.author.lattes7438704034471673
unesp.author.lattes4563764623232492[3]
unesp.author.orcid0000-0002-5980-4367[15]
unesp.author.orcid0000-0002-5056-5734[6]
unesp.author.orcid0000-0002-2875-9532[3]
unesp.author.orcid0000-0001-8825-6980[1]
unesp.author.orcid0000-0003-4412-1990[13]
unesp.author.orcid0000-0002-5843-6232[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000290594900015.pdf
Tamanho:
239.56 KB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Clínica Médica - FMB
Artigos - Microbiologia e Imunologia - IBB
Artigos - Química e Bioquímica - IBB