Head and neck carcinogenesis: Impact of MTHFD1 G1958A polymorphism

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dc.contributor.authorda Silva, Lidia Maria Rebolho Batista
dc.contributor.authorda Silva, Jéssika Nunes Gomes
dc.contributor.authorGalbiatti, Ana Lívia Silva
dc.contributor.authorSucci, Maysa
dc.contributor.authorRuiz, Mariangela Torreglosa [UNESP]
dc.contributor.authorRaposo, Luiz Sérgio
dc.contributor.authorManiglia, José Víctor
dc.contributor.authorPavarino-Bertelli, Érika Cristina
dc.contributor.authorGoloni-Bertollo, Eny Maria
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:25:28Z
dc.date.available2014-05-27T11:25:28Z
dc.date.issued2011-03-01
dc.description.abstractObjective: To investigate the MTHFD1 G1958A polymorphism involved in the folate metabolism as a risk for head and neck cancer, and to find the association of the polymorphism with the risk factors and clinical and histopathological characteristics. Methods: Retrospective study investigating MTHFD1 G1958A polymorphism in 694 subjects (240 patients in the Case Group and 454 in the Control Group) by Restriction Fragment Length Polymorphism (RFLP) Analysis. Multiple logistic regression and chi-square tests were used in the statistical analysis. Results: Multivariable analysis showed that smoking and age over 42 years were disease predictors (p < 0.05). MTHFD1 1958GA or AA genotypes were associated with smoking (p = 0.04) and alcoholism (p = 0.03) and were more ofen found in more advanced stage tumors (p = 0.04) and in patients with a shorter survival (p = 0.03). Conclusion: Te presence of MTHFD1 G1948A polymorphism associated with smoking and alcoholism raises the head and neck cancer risk.en
dc.description.affiliationResearch in Genetics and Molecular Biology -UPGEM Medical College of São José do Rio Preto - FAMERP, São José do Rio Preto, SP
dc.description.affiliationLanguage and Hearing Sciences FAMERP, São José do Rio Preto, SP
dc.description.affiliationUPGEM/ FAMERP, São José do Rio Preto, SP
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho - Unesp, São José do Rio Preto, SP
dc.description.affiliationFAMERP, São José do Rio Preto, SP
dc.description.affiliationDepartment of Otorhinolaryngology and Head and Neck Surgery FAMERP, São José do Rio
dc.description.affiliationDepartment of Molecular Biology FAMERP, São José do Rio Preto, SP
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho - Unesp, São José do Rio Preto, SP
dc.format.extent188-193
dc.identifierhttp://dx.doi.org/10.1016/S2255-4823(11)70043-1
dc.identifier.citationRevista da Associacao Medica Brasileira, v. 57, n. 2, p. 188-193, 2011.
dc.identifier.doi10.1016/S2255-4823(11)70043-1
dc.identifier.file2-s2.0-79955739445.pdf
dc.identifier.issn0104-4230
dc.identifier.scopus2-s2.0-79955739445
dc.identifier.urihttp://hdl.handle.net/11449/72320
dc.language.isoeng
dc.relation.ispartofRevista da Associação Médica Brasileira
dc.relation.ispartofjcr0.736
dc.relation.ispartofsjr0,265
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAlcoholism
dc.subjectGenetic
dc.subjectHead and neck neoplasms
dc.subjectMe-hylenetetrahydrofolate dehydrogenase (NADP)
dc.subjectPolymorphism
dc.subjectSmoking
dc.titleHead and neck carcinogenesis: Impact of MTHFD1 G1958A polymorphismen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy

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