New palladium(II) complexes with pyrazole ligands Part I. Synthesis, spectral and thermal studies, and antitumor evaluation
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Data
2011-11-01
Autores
Barra, Carolina V. [UNESP]
Rocha, Fillipe V. [UNESP]
Netto, Adelino Vieira de Godoy [UNESP]
Shimura, B. [UNESP]
Frem, Regina Célia Galvão [UNESP]
Mauro, Antonio Eduardo [UNESP]
Carlos, Iracilda Z. [UNESP]
Ananias, Sandra R. [UNESP]
Quilles, Marcela B. [UNESP]
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Editor
Springer
Resumo
The pyrazole ligand 3,5-dimethyl-4-iodopyrazole (HdmIPz) has been used to obtain a series of palladium(II) complexes (1-4) of the type [PdX(2)(HdmIPz)(2)] {X = Cl(-) (1); Br(-) (2); I(-) (3); SCN(-) (4)}. All compounds have been isolated, purified, and characterized by means of elemental analysis, IR spectroscopy, (1)H and (13)C{(1)H}-NMR experiments, differential thermal analysis (DTA), and thermogravimetry (TG). The TG/DTA curves showed that the compounds released ligands in the temperature range 137-605 A degrees C, yielding metallic palladium as final residue. The complexes and the ligand together with cisplatin have been tested in vitro by MTT assay for their cytotoxicity against two murine cancer cell lines: mammary adenocarcinoma (LM3) and lung adenocarcinoma (LP07).
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Palavras-chave
Palladium(II), Pyrazoles, IR and NMR spectroscopy, Thermal behavior
Como citar
Journal of Thermal Analysis and Calorimetry. Dordrecht: Springer, v. 106, n. 2, p. 483-488, 2011.