Transcriptomic Profiling of Rectus Abdominis Muscle in Women with Gestational Diabetes-Induced Myopathy: Characterization of Pathophysiology and Potential Muscle Biomarkers of Pregnancy-Specific Urinary Incontinence

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dc.contributor.authorAlves, Fernanda Cristina Bergamo [UNESP]
dc.contributor.authorOliveira, Rafael Guilen de [UNESP]
dc.contributor.authorReyes, David Rafael Abreu [UNESP]
dc.contributor.authorGarcia, Gabriela Azevedo [UNESP]
dc.contributor.authorFloriano, Juliana Ferreira [UNESP]
dc.contributor.authorShetty, Raghavendra Hallur Lakshmana [UNESP]
dc.contributor.authorMareco, Edson Assunção
dc.contributor.authorDal-Pai-Silva, Maeli [UNESP]
dc.contributor.authorPayão, Spencer Luiz Marques
dc.contributor.authorSouza, Fátima Pereira de [UNESP]
dc.contributor.authorWitkin, Steven S.
dc.contributor.authorSobrevia, Luis [UNESP]
dc.contributor.authorBarbosa, Angélica Mércia Pascon [UNESP]
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionPravara Institute of Medical Sciences
dc.contributor.institutionUniversity of Western São Paulo (UNOESTE)
dc.contributor.institutionFaculdade de Medicina de Marília (FAMEMA)
dc.contributor.institutionWeill Cornell Medicine
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionPontificia Universidad Católica de Chile
dc.contributor.institutionUniversidad de Sevilla
dc.contributor.institutionUniversity of Queensland
dc.contributor.institutionUniversity of Groningen
dc.contributor.institutionSchool of Medicine and Health Sciences
dc.date.accessioned2023-07-29T13:28:46Z
dc.date.available2023-07-29T13:28:46Z
dc.date.issued2022-11-01
dc.description.abstractGestational diabetes mellitus (GDM) is recognized as a “window of opportunity” for the future prediction of such complications as type 2 diabetes mellitus and pelvic floor muscle disorders, including urinary incontinence and genitourinary dysfunction. Translational studies have reported that pelvic floor muscle disorders are due to a GDM-induced-myopathy (GDiM) of the pelvic floor muscle and rectus abdominis muscle (RAM). We now describe the transcriptome profiling of the RAM obtained by Cesarean section from GDM and non-GDM women with and without pregnancy-specific urinary incontinence (PSUI). We identified 650 genes in total, and the differentially expressed genes were defined by comparing three control groups to the GDM with PSUI group (GDiM). Enrichment analysis showed that GDM with PSUI was associated with decreased gene expression related to muscle structure and muscle protein synthesis, the reduced ability of muscle fibers to ameliorate muscle damage, and the altered the maintenance and generation of energy through glycogenesis. Potential genetic muscle biomarkers were validated by RT-PCR, and their relationship to the pathophysiology of the disease was verified. These findings help elucidate the molecular mechanisms of GDiM and will promote the development of innovative interventions to prevent and treat complications such as post-GDM urinary incontinence.en
dc.description.affiliationDepartment of Gynecology and Obstetrics Botucatu Medical School São Paulo State University
dc.description.affiliationMaterials Science and Technology (POSMAT) School of Sciences São Paulo State University (UNESP
dc.description.affiliationCenter for Biotechnology Pravara Institute of Medical Sciences, Rahata Taluk, Ahmednagar District
dc.description.affiliationEnvironment and Regional Development Graduate Program University of Western São Paulo (UNOESTE)
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationDepartment of Genetics Faculdade de Medicina de Marília (FAMEMA)
dc.description.affiliationDepartment of Physics UNESP-IBILCE
dc.description.affiliationDepartment of Obstetrics and Gynecology Weill Cornell Medicine
dc.description.affiliationLaboratory of Virology Institute of Tropical Medicine University of Sao Paulo Faculty of Medicine
dc.description.affiliationCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile
dc.description.affiliationDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla
dc.description.affiliationFaculty of Medicine and Biomedical Sciences University of Queensland
dc.description.affiliationDepartment of Pathology and Medical Biology University of Groningen
dc.description.affiliationTecnologico de Monterrey Eutra The Institute for Obesity Research (IOR) School of Medicine and Health Sciences
dc.description.affiliationDepartment of Physiotherapy and Occupational Therapy School of Philosophy and Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Gynecology and Obstetrics Botucatu Medical School São Paulo State University
dc.description.affiliationUnespMaterials Science and Technology (POSMAT) School of Sciences São Paulo State University (UNESP
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Physics UNESP-IBILCE
dc.description.affiliationUnespDepartment of Physiotherapy and Occupational Therapy School of Philosophy and Sciences São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.3390/ijms232112864
dc.identifier.citationInternational Journal of Molecular Sciences, v. 23, n. 21, 2022.
dc.identifier.doi10.3390/ijms232112864
dc.identifier.issn1422-0067
dc.identifier.issn1661-6596
dc.identifier.scopus2-s2.0-85141966645
dc.identifier.urihttp://hdl.handle.net/11449/247890
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.sourceScopus
dc.subjectgestational diabetes mellitus (GDM)
dc.subjectgestational diabetic-induced myopathy (GDiM)
dc.subjectpregnancy-specific urinary incontinence (PSUI)
dc.subjectrectus abdominis muscle (RAM)
dc.subjecttranscriptomic profile
dc.titleTranscriptomic Profiling of Rectus Abdominis Muscle in Women with Gestational Diabetes-Induced Myopathy: Characterization of Pathophysiology and Potential Muscle Biomarkers of Pregnancy-Specific Urinary Incontinenceen
dc.typeArtigo
unesp.author.orcid0000-0002-4640-5332[1]
unesp.author.orcid0000-0002-1700-5890[2]
unesp.author.orcid0000-0003-4300-109X[6]
unesp.author.orcid0000-0002-3504-6936[7]
unesp.author.orcid0000-0001-7269-9197[8]
unesp.author.orcid0000-0001-5802-2243[12]
unesp.author.orcid0000-0002-9227-832X[14]

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Artigos - Ginecologia e Obstetrícia - FMB
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