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Heart failure alters matrix metalloproteinase gene expression and activity in rat skeletal muscle

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dc.contributor.authorCarvalho, Robson Francisco
dc.contributor.authorDariolli, Rafael
dc.contributor.authorJustulin Junior, Luis Antonio
dc.contributor.authorSugizaki, Mario Mateus
dc.contributor.authorOkoshi, Marina Politi [UNESP]
dc.contributor.authorCicogna, Antonio Carlos [UNESP]
dc.contributor.authorFelisbino, Sergio Luis
dc.contributor.authorDal Pai-Silva, Maeli
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-20T13:32:52Z
dc.date.available2014-05-20T13:32:52Z
dc.date.issued2006-12-01
dc.description.abstractHeart failure is associated with a skeletal muscle myopathy with cellular and extracellular alterations. The hypothesis of this investigation is that extracellular changes may be associated with enhanced mRNA expression and activity of matrix metalloproteinases (MMP). We examined MMP mRNA expression and MMP activity in Soleus (SOL), extensor digitorum longus (EDL), and diaphragm (DIA) muscles of young Wistar rat with monocrotaline-induced heart failure. Rats injected with saline served as age-matched controls. MMP2 and MMP9 mRNA contents were determined by RT-PCR and MMP activity by electrophoresis in gelatin-containing polyacrylamide gels in the presence of SDS under non-reducing conditions. Heart failure increased MMP9 mRNA expression and activity in SOL, EDL and DIA and MMP2 mRNA expression in DIA. These results suggest that MMP changes may contribute to the skeletal muscle myopathy during heart failure.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Dept Morphol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Biol Celular, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Dept Clin Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Dept Morphol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Dept Clin Med, Botucatu, SP, Brazil
dc.format.extent437-443
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2613.2006.00497.x
dc.identifier.citationInternational Journal of Experimental Pathology. Oxford: Blackwell Publishing, v. 87, n. 6, p. 437-443, 2006.
dc.identifier.doi10.1111/j.1365-2613.2006.00497.x
dc.identifier.issn0959-9673
dc.identifier.lattes7263490918934874
dc.identifier.lattes5406518799128485
dc.identifier.lattes9418970103564137
dc.identifier.lattes4463138671998432
dc.identifier.lattes8152477449159336
dc.identifier.orcid0000-0002-4901-7714
dc.identifier.orcid0000-0002-7358-3302
dc.identifier.urihttp://hdl.handle.net/11449/11226
dc.identifier.wosWOS:000242221900004
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofInternational Journal of Experimental Pathology
dc.relation.ispartofjcr1.938
dc.relation.ispartofsjr0,712
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectextracellular matrixpt
dc.subjectheart failurept
dc.subjectmetalloproteinasespt
dc.subjectskeletal musclept
dc.subjectWistar ratspt
dc.titleHeart failure alters matrix metalloproteinase gene expression and activity in rat skeletal muscleen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderBlackwell Publishing
dspace.entity.typePublication
unesp.author.lattes7263490918934874
unesp.author.lattes5406518799128485
unesp.author.lattes9418970103564137[6]
unesp.author.lattes4463138671998432
unesp.author.lattes8152477449159336
unesp.author.orcid0000-0002-4901-7714[1]
unesp.author.orcid0000-0002-7358-3302
unesp.author.orcid0000-0002-4402-6523[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentClínica Médica - FMBpt
unesp.departmentMorfologia - IBBpt

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Botucatu - IBB - Instituto de Biociências
Botucatu - FMB - Faculdade de Medicina