EGFR is not amplified in ameloblastoma
dc.contributor.author | Costa, Victor [UNESP] | |
dc.contributor.author | Fregnani, Eduardo Rodrigues | |
dc.contributor.author | Fonseca, Felipe Paiva | |
dc.contributor.author | Abreu Alves, Fábio | |
dc.contributor.author | Pinto, Clóvis Antônio Lopes | |
dc.contributor.author | Kaminagakura, Estela [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Sírio-Libanês Hospital | |
dc.contributor.institution | Universidade Federal de Minas Gerais (UFMG) | |
dc.contributor.institution | A.C. Camargo Cancer Center | |
dc.date.accessioned | 2018-12-11T16:52:33Z | |
dc.date.available | 2018-12-11T16:52:33Z | |
dc.date.issued | 2018-05-01 | |
dc.description.abstract | Objective: The aim of this study was to investigate alterations in the EGFR gene and its protein expression for a better understanding of the biologic behavior of ameloblastoma. Study Design: Twenty-five samples of ameloblastoma were selected, and dual-color fluorescence in situ hybridization assay was performed. The results of the assay and immunohistochemistry reaction for EGFR and Ki67 were associated with clinicopathologic features and recurrence. Results: All analyzed cases presented disomy without any gene polysomy or amplification. With regard to EGFR immunoexpression, 3 cases (12%) were considered negative, and 22 (88%) were positive, of which 13 (52%) were weak and 9 (36%) were strong. All samples presented low positivity for Ki67. There was no association between EGFR expression and clinicopathologic features or recurrence (P >.05). In some cases, EGFR immunoexpression was observed without gene amplification. Conclusions: Ameloblastoma development, progression, or recurrence does not appear to be related to EGFR amplification or polysomy. | en |
dc.description.affiliation | Department of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (Unesp) | |
dc.description.affiliation | Department of Oral Medicine Sírio-Libanês Hospital | |
dc.description.affiliation | Department of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas Gerais | |
dc.description.affiliation | Department of Stomatology A.C. Camargo Cancer Center | |
dc.description.affiliation | Department of Anatomic Pathology A.C. Camargo Cancer Center | |
dc.description.affiliationUnesp | Department of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (Unesp) | |
dc.format.extent | 454-458 | |
dc.identifier | http://dx.doi.org/10.1016/j.oooo.2018.02.014 | |
dc.identifier.citation | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, v. 125, n. 5, p. 454-458, 2018. | |
dc.identifier.doi | 10.1016/j.oooo.2018.02.014 | |
dc.identifier.file | 2-s2.0-85044359549.pdf | |
dc.identifier.issn | 2212-4403 | |
dc.identifier.scopus | 2-s2.0-85044359549 | |
dc.identifier.uri | http://hdl.handle.net/11449/170820 | |
dc.language.iso | eng | |
dc.relation.ispartof | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology | |
dc.relation.ispartofsjr | 0,720 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Scopus | |
dc.title | EGFR is not amplified in ameloblastoma | en |
dc.type | Artigo |
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