Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates
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Undergraduate course
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Acesso aberto
Abstract
We reported in this work the preparation of novel 1,4-disubstituted-1,2,3-triazoles derivatives from Dglucose and D-fructose and their in vitro antibacterial activity against Mycobacterium tuberculosis were evaluated. The chemical synthesis was performed based on the 1,3-dipolar cycloaddition reaction, and antimicrobial activity was determined based on Resazurin Microtiter Assay against Mycobacterium. None of the triazole glycoconjugates tested showed activity against these microorganisms.
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Keywords
Carbohydrate, Glycoconjugates, 1,2,3-triazole, Antitubercular activity
Language
English
Citation
Mediterranean Journal of Chemistry, v. 1, n. 6, p. 281-288, 2012.
