Publicação: Dual-protected amino acid derivatives as new antitubercular agents
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Wiley-Blackwell
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Resumo
Tuberculosis is an infectious disease with high incidence and growing drug-resistant rates. In an attempt to develop new antitubercular agents, 35 compounds were synthesized, most of them bearing a carbamate and enantiopure amino acid moiety. These compounds had their activity evaluated toward a Mycobacterium tuberculosis strain (ATCC 27294) and cytotoxicity against fibroblast MRC-5 cells (ATCC CCL-171). Three of the prepared derivatives presented a good antimicrobial inhibition and two of them a moderate cytotoxicity. The lipophilicity seems to play a vital role in the cell growth activity, with best results for the derivatives with a higher logP.
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amino acid, carbamate, cytotoxicity, Mycobacterium tuberculosis
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Inglês
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Chemical Biology & Drug Design. Hoboken: Wiley, v. 92, n. 2, p. 1576-1580, 2018.
