Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia
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Undergraduate course
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Article
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Acesso aberto
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Abstract
Strategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with a high selectivity for the target cells, and 2) selective gene delivery encoding an enzyme that can promote the prodrug to a citotoxic drug for the target cells. In this article are discussed ADEPT (antibody-directed enzyme prodrug therapy), GDEPT (gene-directed enzyme prodrug therapy), VDEPT (virus-directed enzyme prodrug therapy), GPAT (genetic prodrug activation therapy) and PDEPT (polymer-directed enzyme prodrug therapy) approaches, their clinical trials, advantages, disadvantages and perspectives.
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Keywords
Cancer, Enzymes, Prodrugs
Language
Portuguese
Citation
Quimica Nova, v. 29, n. 6, p. 1307-1316, 2006.
