Contribuição do uso de medicamentos para a admissão hospitalar
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FapUNIFESP (SciELO)
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Resumo
According to the Word Health Organization, adverse drug reactions (ADR) are any harmful and non intentional answer which occurred in doses normally used in human beings. The ADR can be responsible for 2.4% to 11.5% of hospital admissions. Therefore, this study aimed at knowing the admitted patient's demographic profile due to possible ADR, identifying the most frequent drugs and complaints, and evaluating the incidence of hospital admission related to drug use. Patients who were 18 years old or more and were admitted during a period of one month to a medical clinical of a general hospital were interviewed for one month about drug use before being admitted, as well as regarding to the complaint which led them to hospital. These information were analyzed according to official data, like MICROMEDEX® and WHO criteria as well. It was observed that the admission due to drug use occurred in most part of the cases in elderly [47.5% (66/139)] and women [62% (87/139)]. The most frequent drugs used were: omeprazole (16), analgesics (31), antihypertensive (31), simvastatin (7) and formoterol fumarate (6), and the symptoms were normally associated to the digestive (20.5%), circulatory (20.2%), respiratory (18.2%) and central nervous systems (13.9%). It was estimated that 15.5% (139/897) of the hospital admission occurred possibly due to the drug use. The data found by present study suggests some strategies in order to prevent ADR in the context of primary health care services, such as monitoring drug therapy, manly for patients with chronic diseases, elderly and polimedicated people; and pharmaceutical care including dispensation and purchasing of the drugs, a lot of them dispensed over the counter (OTC).
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Drugs/adverse reactions Drugs/rational use Pharmaceutical attention Pharmacotherapeutic care acetylsalicylic acid amiodarone analgesic agent antihypertensive agent atenolol captopril dipyrone enalapril formoterol formoterol fumarate non prescription drug omeprazole paracetamol simvastatin adult age distribution arterial pressure asthma bronchospasm chronic disease congestive heart failure data analysis demography diabetes mellitus drug use dyspnea female fever gastrointestinal disease gastrointestinal symptom headache heart beat heart infarction hospitalization human kidney failure major clinical study male mucosa inflammation muscle disease myalgia nausea osteoarthritis patient monitoring pharmaceutical care pneumonia primary health care rash sex ratio side effect somnolence symptom urine retention vomiting world health organization
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Português
Citação
Brazilian Journal of Pharmaceutical Sciences, v. 45, n. 1, p. 163-170, 2009.
