Adverse drug reaction as cause of hospital admission of elderly people: a pilot study
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The objective of this study was to estimate the prevalence of adverse drug reactions (ADR) related to hospital admission of elderly people, identifying the use of potentially inappropriate medication (PIM), the ADR and the risk factors associated with the hospitalization. A cross-sectional study was conducted in a private hospital of São Paulo State, Brazil. All patients aged ≥ 60 years, admitted in the general practice ward in May 2006 were interviewed about the drugs used and the symptoms/complaints that resulted in hospitalization. More than a half (54.5 %) of elderly hospitalizations were related with ADR. The therapeutic classes involved with ADR were: cardiovascular (37.7 %), central nervous (34.6 %) and respiratory (5.7 %). The ADR observed were disorders in circulatory (28.4 %), digestive (20.0 %) and respiratory (18.9 %) tracts. 27 elderly had made PIM and in 20 of them this was the cause of hospitalization. Polypharmacy was an ADR risk factor (p = 0.021).These data allows the healthcare professionals upgrade, qualifying them in pharmcovigilance.
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Adverse drug reaction Elderly people Hospital admission Use of drugs acetylsalicylic acid atenolol bromazepam captopril clopidogrel dipyrone enalapril nitric acid derivative omeprazole propatilnitrate simvastatin unclassified drug abdominal pain adult adverse drug reaction aged allergic reaction angina pectoris angioneurotic edema arthralgia asthma attention deficit disorder bleeding Brazil bronchospasm cardiovascular disease central nervous system disease constipation controlled study cross-sectional study digestive system function disorder digestive system ulcer dizziness dyspepsia dyspnea gastrointestinal disease gastrointestinal hemorrhage geriatric patient heart arrhythmia heart failure hospital admission human hypertension hypotension lung disease lung edema lung insufficiency major clinical study muscle weakness myalgia nausea neuralgia orthostatic hypotension pilot study pneumonia polypharmacy prescription prevalence private hospital respiratory tract disease risk factor somnolence symptomatology syncope tachycardia vertigo visual disorder vomiting
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Inglês
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Latin American Journal of Pharmacy, v. 30, n. 2, p. 347-, 2011.
