Show simple item record

dc.contributor.authorRossi, Danuza [UNESP]
dc.contributor.authorKuroshu, Reginaldo
dc.contributor.authorZanelli, Cleslei Fernando [UNESP]
dc.contributor.authorValentini, Sandro Roberto [UNESP]
dc.date.accessioned2014-12-03T13:11:43Z
dc.date.available2014-12-03T13:11:43Z
dc.date.issued2014-03-01
dc.identifierhttp://dx.doi.org/10.1002/wrna.1211
dc.identifier.citationWiley Interdisciplinary Reviews-rna. Hoboken: Wiley-blackwell, v. 5, n. 2, p. 209-222, 2014.
dc.identifier.issn1757-7004
dc.identifier.urihttp://hdl.handle.net/11449/113452
dc.description.abstractTranslational control is extremely important in all organisms, and some of its aspects are highly conserved among all primary kingdoms, such as those related to the translation elongation step. The previously classified translation initiation factor 5A (eIF5A) and its bacterial homologue elongation factor P (EF-P) were discovered in the late 70's and have recently been the object of many studies. eIF5A and EF-P are the only cellular proteins that undergo hypusination and lysinylation, respectively, both of which are unique posttranslational modifications. Herein, we review all the important discoveries related to the biochemical and functional characterization of these factors, highlighting the implication of eIF5A in translation elongation instead of initiation. The findings that eIF5A and EF-P are important for specific cellular processes and play a role in the relief of ribosome stalling caused by specific amino acid sequences, such as those containing prolines reinforce the hypothesis that these factors are involved in specialized translation. Although there are some divergences between these unique factors, recent studies have clarified that they act similarly during protein synthesis. Further studies may reveal their precise mechanism of ribosome activity modulation as well as the mRNA targets that require eIF5A and EF-P for their proper translation. (C) 2014 John Wiley & Sons, Ltd.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent209-222
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofWiley Interdisciplinary Reviews-rna
dc.sourceWeb of Science
dc.titleeIF5A and EF-P: two unique translation factors are now traveling the same roaden
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Biol Sci, Sch Pharmaceut Sci, Araraquara, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Inst Sci & Technol, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Biol Sci, Sch Pharmaceut Sci, Araraquara, SP, Brazil
dc.identifier.doi10.1002/wrna.1211
dc.identifier.wosWOS:000331210700004
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
dc.identifier.lattes5333250355049814
unesp.author.lattes5333250355049814
dc.relation.ispartofjcr5.844
dc.relation.ispartofsjr4,220
Localize o texto completo

Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record